Patients' perspectives on antiepileptic medication: relationships between beliefs about medicines and adherence among patients with epilepsy in UK primary care

S C E Chapman, R Horne, A Chater, D Hukins, W H Smithson

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

BACKGROUND: Nonadherence to antiepileptic drugs (AEDs) can result in suboptimal outcomes for patients.

AIM: This study aimed to assess the utility of a theory-based approach to understanding patient perspectives on AEDs and adherence.

METHOD: Patients with epilepsy, identified by a GP case note review, were mailed validated questionnaires assessing their perceptions of AEDs and their adherence to them.

RESULTS: Most (84.9%) of the 398 AED-treated respondents accepted the necessity of AEDs, but over half expressed doubts, with 55% disagreeing or uncertain about the statement 'I would prefer to take epilepsy medication than risk a seizure'. Over a third (36.4%) expressed strong concerns about the potential negative effects of AEDs. We used self-report and medication possession ratio to classify 36.4% of patients as nonadherent. Nonadherence was related to beliefs about medicines and implicit attitudes toward AEDs (p<0.05). Adherence-related attitudes toward AEDs were correlated with general beliefs about pharmaceuticals (BMQ General: General Harm, General Overuse, and General Benefit scales) and perceptions of personal sensitivity to medicines (PSM scale).

CONCLUSION: We identified salient, adherence-related beliefs about AEDs. Patient-centered interventions to support medicine optimization for people with epilepsy should take account of these beliefs.

Original languageEnglish
Pages (from-to)312-320
Number of pages9
JournalEpilepsy and Behavior
Volume31
DOIs
Publication statusPublished - Feb 2014

Keywords

  • Adult
  • Aged
  • Anticonvulsants
  • Culture
  • Epilepsy
  • Female
  • Great Britain
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Male
  • Medication Adherence
  • Middle Aged
  • Perception
  • Primary Health Care
  • Severity of Illness Index
  • Journal Article
  • Research Support, Non-U.S. Gov't

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