Pathogen perception by NLRs in plants and animals

Parallel worlds

Zane Duxbury, Yan Ma, Oliver J Furzer, Sung Un Huh, Volkan Cevik, Jonathan D G Jones, Panagiotis F Sarris

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Intracellular NLR (Nucleotide-binding domain and Leucine-rich Repeat-containing) receptors are sensitive monitors that detect pathogen invasion of both plant and animal cells. NLRs confer recognition of diverse molecules associated with pathogen invasion. NLRs must exhibit strict intramolecular controls to avoid harmful ectopic activation in the absence of pathogens. Recent discoveries have elucidated the assembly and structure of oligomeric NLR signalling complexes in animals, and provided insights into how these complexes act as scaffolds for signal transduction. In plants, recent advances have provided novel insights into signalling-competent NLRs, and into the myriad strategies that diverse plant NLRs use to recognise pathogens. Here, we review recent insights into the NLR biology of both animals and plants. By assessing commonalities and differences between kingdoms, we are able to develop a more complete understanding of NLR function.

Original languageEnglish
Pages (from-to)769-81
Number of pages13
JournalBioessays
Volume38
Issue number8
Early online date24 Jun 2016
DOIs
Publication statusPublished - Aug 2016

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Pathogens
Animals
Plant Cells
Leucine
Signal transduction
Signal Transduction
Scaffolds (biology)
Nucleotides
Chemical activation
Cells
Molecules

Keywords

  • Journal Article

Cite this

Duxbury, Z., Ma, Y., Furzer, O. J., Huh, S. U., Cevik, V., Jones, J. D. G., & Sarris, P. F. (2016). Pathogen perception by NLRs in plants and animals: Parallel worlds. Bioessays, 38(8), 769-81. https://doi.org/10.1002/bies.201600046

Pathogen perception by NLRs in plants and animals : Parallel worlds. / Duxbury, Zane; Ma, Yan; Furzer, Oliver J; Huh, Sung Un; Cevik, Volkan; Jones, Jonathan D G; Sarris, Panagiotis F.

In: Bioessays, Vol. 38, No. 8, 08.2016, p. 769-81.

Research output: Contribution to journalArticle

Duxbury, Z, Ma, Y, Furzer, OJ, Huh, SU, Cevik, V, Jones, JDG & Sarris, PF 2016, 'Pathogen perception by NLRs in plants and animals: Parallel worlds', Bioessays, vol. 38, no. 8, pp. 769-81. https://doi.org/10.1002/bies.201600046
Duxbury, Zane ; Ma, Yan ; Furzer, Oliver J ; Huh, Sung Un ; Cevik, Volkan ; Jones, Jonathan D G ; Sarris, Panagiotis F. / Pathogen perception by NLRs in plants and animals : Parallel worlds. In: Bioessays. 2016 ; Vol. 38, No. 8. pp. 769-81.
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