Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate

Giordano Pula; Elena Garonna; Warwick B Dunn; Michio Hirano; Giuseppe Pizzorno; Michelangelo Campanella; Edward L Schwartz; Mahmoud H El Kouni; Caroline P D Wheeler-Jones

doi:10.1161/ATVBAHA.110.215855

Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate

Giordano Pula
, Elena Garonna
, Warwick B Dunn
, Michio Hirano
, Giuseppe Pizzorno
, Michelangelo Campanella
, Edward L Schwartz
, Mahmoud H El Kouni
, Caroline P D Wheeler-Jones

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (SciVal)

Abstract

Platelet-derived dRP stimulates endothelial cell migration by upregulating integrin β(3) in a reactive oxygen species-dependent manner. As demonstrated by our in vivo experiments, this novel paracrine regulatory pathway is likely to play an important role in the stimulation of angiogenesis by platelets.

Original language	English
Pages (from-to)	2631-2638
Number of pages	8
Journal	Arteriosclerosis, thrombosis, and vascular biology
Volume	30
Issue number	12
DOIs	https://doi.org/10.1161/ATVBAHA.110.215855
Publication status	Published - 2010

Access to Document

10.1161/ATVBAHA.110.215855

Cite this

Pula, G., Garonna, E., Dunn, W. B., Hirano, M., Pizzorno, G., Campanella, M., Schwartz, E. L., El Kouni, M. H., & Wheeler-Jones, C. P. D. (2010). Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate. Arteriosclerosis, thrombosis, and vascular biology, 30(12), 2631-2638. https://doi.org/10.1161/ATVBAHA.110.215855

@article{437fc3406b1e440db0be2143d360a792,

title = "Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate",

abstract = "Platelet-derived dRP stimulates endothelial cell migration by upregulating integrin β(3) in a reactive oxygen species-dependent manner. As demonstrated by our in vivo experiments, this novel paracrine regulatory pathway is likely to play an important role in the stimulation of angiogenesis by platelets.",

author = "Giordano Pula and Elena Garonna and Dunn, \{Warwick B\} and Michio Hirano and Giuseppe Pizzorno and Michelangelo Campanella and Schwartz, \{Edward L\} and \{El Kouni\}, \{Mahmoud H\} and Wheeler-Jones, \{Caroline P D\}",

year = "2010",

doi = "10.1161/ATVBAHA.110.215855",

language = "English",

volume = "30",

pages = "2631--2638",

journal = "Arteriosclerosis, thrombosis, and vascular biology",

issn = "1524-4636",

publisher = "Lippincott Williams and Wilkins",

number = "12",

}

TY - JOUR

T1 - Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate

AU - Pula, Giordano

AU - Garonna, Elena

AU - Dunn, Warwick B

AU - Hirano, Michio

AU - Pizzorno, Giuseppe

AU - Campanella, Michelangelo

AU - Schwartz, Edward L

AU - El Kouni, Mahmoud H

AU - Wheeler-Jones, Caroline P D

PY - 2010

Y1 - 2010

N2 - Platelet-derived dRP stimulates endothelial cell migration by upregulating integrin β(3) in a reactive oxygen species-dependent manner. As demonstrated by our in vivo experiments, this novel paracrine regulatory pathway is likely to play an important role in the stimulation of angiogenesis by platelets.

AB - Platelet-derived dRP stimulates endothelial cell migration by upregulating integrin β(3) in a reactive oxygen species-dependent manner. As demonstrated by our in vivo experiments, this novel paracrine regulatory pathway is likely to play an important role in the stimulation of angiogenesis by platelets.

UR - https://www.scopus.com/pages/publications/78650420402

UR - http://dx.doi.org/10.1161/ATVBAHA.110.215855

U2 - 10.1161/ATVBAHA.110.215855

DO - 10.1161/ATVBAHA.110.215855

M3 - Article

SN - 1524-4636

VL - 30

SP - 2631

EP - 2638

JO - Arteriosclerosis, thrombosis, and vascular biology

JF - Arteriosclerosis, thrombosis, and vascular biology

IS - 12

ER -

Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate

Abstract

Access to Document

Other files and links

Fingerprint

Cite this