Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate

Giordano Pula, Elena Garonna, Warwick B Dunn, Michio Hirano, Giuseppe Pizzorno, Michelangelo Campanella, Edward L Schwartz, Mahmoud H El Kouni, Caroline P D Wheeler-Jones

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Platelet-derived dRP stimulates endothelial cell migration by upregulating integrin β(3) in a reactive oxygen species-dependent manner. As demonstrated by our in vivo experiments, this novel paracrine regulatory pathway is likely to play an important role in the stimulation of angiogenesis by platelets.
Original languageEnglish
Pages (from-to)2631-2638
Number of pages8
JournalArteriosclerosis, thrombosis, and vascular biology
Volume30
Issue number12
DOIs
Publication statusPublished - 2010

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