Abstract
A palladium-catalyzed domino arylation-cyclization of biocatalytically derived cyclic 1,3-dienes is demonstrated. The reaction introduces a high degree of structural complexity in a single step, giving access to tricyclic tetrahydrofluorenones with full regio- and stereoselectivity. The transformation proceeds through a novel acylation-terminated Heck-type sequence, and quantum chemical calculations indicate that C-H activation is involved in the terminating acylation step.
| Original language | English |
|---|---|
| Pages (from-to) | 6518-6521 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 57 |
| Issue number | 53 |
| Early online date | 2 Jun 2021 |
| DOIs | |
| Publication status | Published - 7 Jul 2021 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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