Abstract
An efficient palladium-catalyzed synthesis of 1,2-dihydroquinolines has been developed via the reaction between anilines and Morita–Baylis–Hillman adducts derived from o-bromobenzaldehyde. This new Pd(0)-catalyzed pseudo-domino type I sequence involves a Buchwald–Hartwig arylic amination and an allylic amination. When starting from an o-bromo allylic alcohol, the chronology is arylic amination/allylic arylation. However, the sequence reverses when the reaction is performed on the corresponding o-bromo allylic acetate.
Original language | English |
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Pages (from-to) | 3050-3053 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 15 |
Issue number | 12 |
DOIs | |
Publication status | Published - 4 Jun 2013 |