Palladium Catalysed Coupling Reactions

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter presents the leading advances in the specific areas of palladium catalyzed enantioselective allylic substitution, cross-coupling, and Heck reactions. The palladium catalyzed nucleophilic substitution of allylic compounds is an established, efficient and reliable process, and has become an important tool for the synthetic organic chemist. An interesting series of enantiopore monodentate phoshine ligands, which have carboxylic acid functionality and a cyclobutane or cyclopentane backbone are prepared. The use of phoshine-oxazoline ligands in enantioselective allylic substitution and other reactions is also reviewed. The palladium catalyzed cross-coupling process is established as a practical and efficient method of forming carbon-carbon and carbon-heteroatom bonds utilizing a wide range of coupling partners. Heck reactions provide the common description of a palladium catalyzed coupling of alkenes with aryl or vinyl halides or triflates . The wide utility of the intermolecular Heck reaction in the synthesis of natural products stimulated the search for efficient enantioselective catalysts.
Original languageEnglish
Title of host publicationSecond Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds
Subtitle of host publicationA Modern Comprehensive Treatise
Pages315-350
Number of pages36
Volume5
Edition2
DOIs
Publication statusPublished - 1991

Fingerprint

Palladium
Substitution reactions
Carbon
Cyclobutanes
Ligands
Cyclopentanes
Alkenes
Carboxylic Acids
Biological Products
Catalysts

Cite this

Frost, C. G. (1991). Palladium Catalysed Coupling Reactions. In Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds: A Modern Comprehensive Treatise (2 ed., Vol. 5, pp. 315-350) https://doi.org/10.1016/B978-044453347-0.50425-0

Palladium Catalysed Coupling Reactions. / Frost, C.G.

Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds: A Modern Comprehensive Treatise. Vol. 5 2. ed. 1991. p. 315-350.

Research output: Chapter in Book/Report/Conference proceedingChapter

Frost, CG 1991, Palladium Catalysed Coupling Reactions. in Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds: A Modern Comprehensive Treatise. 2 edn, vol. 5, pp. 315-350. https://doi.org/10.1016/B978-044453347-0.50425-0
Frost CG. Palladium Catalysed Coupling Reactions. In Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds: A Modern Comprehensive Treatise. 2 ed. Vol. 5. 1991. p. 315-350 https://doi.org/10.1016/B978-044453347-0.50425-0
Frost, C.G. / Palladium Catalysed Coupling Reactions. Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds: A Modern Comprehensive Treatise. Vol. 5 2. ed. 1991. pp. 315-350
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