Enantiomerically pure ligands containing a 4,5-dihydrooxazole moiety tethered to an auxiliary sulfur or phosphorus donor have been prepared. These ligands have been exploited for palladium-catalysed asymmetric allylic substitution, providing enantioselectivities of 40-96% ee. The origin of the enantioselectivity in the catalytic reaction is discussed in terms of the steric and electronic influences provided by the ligand.
|Number of pages||8|
|Journal||Journal of the Chemical Society: Perkin Transactions 1|
|Publication status||Published - 1994|
Allen, J. V., Coote, S. J., Dawson, G. J., Frost, C. G., Martin, C. J., & Williams, J. M. J. (1994). Palladium-catalysed asymmetric allylic substitution: A ligand design incorporating steric and electronic effects. Journal of the Chemical Society: Perkin Transactions 1, 1994(15), 2065-2072. https://doi.org/10.1039/P19940002065