Palladium-catalysed asymmetric allylic substitution: A ligand design incorporating steric and electronic effects

J.V. Allen, S.J. Coote, G.J. Dawson, C.G. Frost, C.J. Martin, Jonathan M J Williams

Research output: Contribution to journalArticle

Abstract

Enantiomerically pure ligands containing a 4,5-dihydrooxazole moiety tethered to an auxiliary sulfur or phosphorus donor have been prepared. These ligands have been exploited for palladium-catalysed asymmetric allylic substitution, providing enantioselectivities of 40-96% ee. The origin of the enantioselectivity in the catalytic reaction is discussed in terms of the steric and electronic influences provided by the ligand.
Original languageEnglish
Pages (from-to)2065-2072
Number of pages8
JournalJournal of the Chemical Society: Perkin Transactions 1
Volume1994
Issue number15
DOIs
Publication statusPublished - 1994

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