TY - JOUR
T1 - Palladium-catalysed asymmetric allylic substitution
T2 - A ligand design incorporating steric and electronic effects
AU - Allen, J.V.
AU - Coote, S.J.
AU - Dawson, G.J.
AU - Frost, C.G.
AU - Martin, C.J.
AU - Williams, Jonathan M J
PY - 1994
Y1 - 1994
N2 - Enantiomerically pure ligands containing a 4,5-dihydrooxazole moiety tethered to an auxiliary sulfur or phosphorus donor have been prepared. These ligands have been exploited for palladium-catalysed asymmetric allylic substitution, providing enantioselectivities of 40-96% ee. The origin of the enantioselectivity in the catalytic reaction is discussed in terms of the steric and electronic influences provided by the ligand.
AB - Enantiomerically pure ligands containing a 4,5-dihydrooxazole moiety tethered to an auxiliary sulfur or phosphorus donor have been prepared. These ligands have been exploited for palladium-catalysed asymmetric allylic substitution, providing enantioselectivities of 40-96% ee. The origin of the enantioselectivity in the catalytic reaction is discussed in terms of the steric and electronic influences provided by the ligand.
UR - http://www.scopus.com/inward/record.url?scp=37049079396&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1039/P19940002065
U2 - 10.1039/P19940002065
DO - 10.1039/P19940002065
M3 - Article
AN - SCOPUS:37049079396
SN - 0300-922X
VL - 1994
SP - 2065
EP - 2072
JO - Journal of the Chemical Society: Perkin Transactions 1
JF - Journal of the Chemical Society: Perkin Transactions 1
IS - 15
ER -