1 Citation (Scopus)

Abstract

Seronegative spondyloarthropathies are a group of overlapping forms of inflammatory joint disease, the most common conditions being ankylosing spondylitis and psoriatic arthritis. Other less common conditions include reactive arthritis, enteropathic arthritis and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis). Shared features include a propensity to affect the spine, an association with anterior uveitis, involvement of the enthesis, the absence of rheumatoid factor and an increased frequency of HLA-B27. Psoriatic arthritis has several distinctive characteristics that may vary from patient to patient and include frequent involvement of distal interphalangeal joints, dactylitis, new bone formation within the enthesis, osteolysis and ankylosis. Genetic factors are important, with HLA-CW6-containing haplotypes associated with psoriasis and peripheral joint inflammation, and HLA-B27 associated with axial involvement, especially sacroiliitis. The advent of tumour necrosis factor-α inhibitors provides an important new dimension to treatment options for those with severe or persistently active disease.

LanguageEnglish
Pages190-193
Number of pages4
JournalMedicine
Volume38
Issue number4
DOIs
StatusPublished - 1 Apr 2010

Fingerprint

Spondylarthropathies
HLA-B27 Antigen
Psoriatic Arthritis
Joints
Sacroiliitis
Hyperostosis
Anterior Uveitis
Ankylosis
Osteitis
Reactive Arthritis
Osteolysis
Synovitis
Joint Diseases
Rheumatoid Factor
Ankylosing Spondylitis
Acne Vulgaris
Psoriasis
Osteogenesis
Haplotypes
Arthritis

Keywords

  • enteropathic arthritis
  • enthesopathy
  • HLA-B27
  • psoriasis
  • psoriatic arthritis
  • spondylitis
  • tumour necrosis factor-alpha

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Other seronegative spondyloarthropathies. / McHugh, Neil J.

In: Medicine, Vol. 38, No. 4, 01.04.2010, p. 190-193.

Research output: Contribution to journalReview article

McHugh, Neil J. / Other seronegative spondyloarthropathies. In: Medicine. 2010 ; Vol. 38, No. 4. pp. 190-193.
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