Abstract
Alkylation of the aza-enolates of orthogonally protected chiral bis-lactim ethers with electrophiles proceeds with good levels of diastereocontrol to afford trans-alkylated adducts that can be efficiently deprotected via hydrolysis/hydrogenation procedures to afford non-proteinogenic α-amino acid or dipeptide ester derivatives.
Original language | English |
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Pages (from-to) | 2036-2049 |
Journal | Synthesis |
Volume | 48 |
Issue number | 13 |
Early online date | 26 Apr 2016 |
DOIs | |
Publication status | Published - Jul 2016 |