Origin of beta-cells in regenerating pancreas

K E O'Neill, D Eberhard, D Tosh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The origin of insulin-expressing beta-cells in the adult mammalian pancreas is controversial. During normal tissue turnover and following injury, beta-cells may be replaced by duplication of existing beta-cells.((1)) However, an alternative source of beta-cells has recently been proposed based on neogenesis from a Ngn3-positive population present in regenerating pancreatic ducts.((2)) The appearance of beta-cells from Ngn3-positive progenitors is reminiscent of normal pancreas development, and Ngn3-expressing cells isolated from regenerating pancreas can generate the full repertoire of endocrine phenotypes. The isolation and characterisation of the equivalent human progenitors may represent a significant step forward in the hunt for a cure for diabetes.
Original languageEnglish
Pages (from-to)617-620
Number of pages4
JournalBioessays
Volume30
Issue number7
DOIs
Publication statusPublished - 2008

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Medical problems
Ducts
Pancreas
Insulin
Tissue
Pancreatic Ducts
Phenotype
Wounds and Injuries
Population

Cite this

Origin of beta-cells in regenerating pancreas. / O'Neill, K E; Eberhard, D; Tosh, D.

In: Bioessays, Vol. 30, No. 7, 2008, p. 617-620.

Research output: Contribution to journalArticle

O'Neill, KE, Eberhard, D & Tosh, D 2008, 'Origin of beta-cells in regenerating pancreas', Bioessays, vol. 30, no. 7, pp. 617-620. https://doi.org/10.1002/bies.20779
O'Neill, K E ; Eberhard, D ; Tosh, D. / Origin of beta-cells in regenerating pancreas. In: Bioessays. 2008 ; Vol. 30, No. 7. pp. 617-620.
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