Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.
- Amino Acids/chemistry
- Antineoplastic Agents, Phytogenic/chemistry
- Cell Line, Tumor
- Cell Survival/drug effects
- Coordination Complexes/chemistry
- Guanine/analogs & derivatives
- Reactive Oxygen Species/metabolism