Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Wolfgang Kandioller, Evelyn Balsano, Samuel M Meier, Ute Jungwirth, Simone Göschl, Alexander Roller, Michael A Jakupec, Walter Berger, Bernhard K Keppler, Christian G Hartinger

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)

Abstract

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

Original languageEnglish
Pages (from-to)3348-50
Number of pages3
JournalChemical communications (Cambridge, England)
Volume49
Issue number32
DOIs
Publication statusPublished - 25 Apr 2013

Keywords

  • Amino Acids/chemistry
  • Antineoplastic Agents, Phytogenic/chemistry
  • Cell Line, Tumor
  • Cell Survival/drug effects
  • Coordination Complexes/chemistry
  • Guanine/analogs & derivatives
  • Humans
  • Naphthoquinones/chemistry
  • Osmium/chemistry
  • Reactive Oxygen Species/metabolism
  • Rhodium/chemistry
  • Ruthenium/chemistry

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