Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Wolfgang Kandioller; Evelyn Balsano; Samuel M Meier; Ute Jungwirth; Simone Göschl; Alexander Roller; Michael A Jakupec; Walter Berger; Bernhard K Keppler; Christian G Hartinger

doi:10.1039/c3cc40432c

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Wolfgang Kandioller, Evelyn Balsano, Samuel M Meier, Ute Jungwirth, Simone Göschl, Alexander Roller, Michael A Jakupec, Walter Berger, Bernhard K Keppler, Christian G Hartinger

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

130 Citations (SciVal)

Abstract

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

Original language	English
Pages (from-to)	3348-50
Number of pages	3
Journal	Chemical communications (Cambridge, England)
Volume	49
Issue number	32
DOIs	https://doi.org/10.1039/c3cc40432c
Publication status	Published - 25 Apr 2013

Keywords

Amino Acids/chemistry
Antineoplastic Agents, Phytogenic/chemistry
Cell Line, Tumor
Cell Survival/drug effects
Coordination Complexes/chemistry
Guanine/analogs & derivatives
Humans
Naphthoquinones/chemistry
Osmium/chemistry
Reactive Oxygen Species/metabolism
Rhodium/chemistry
Ruthenium/chemistry

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10.1039/c3cc40432cLicence: CC BY

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Kandioller, W., Balsano, E., Meier, S. M., Jungwirth, U., Göschl, S., Roller, A., Jakupec, M. A., Berger, W., Keppler, B. K., & Hartinger, C. G. (2013). Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity. Chemical communications (Cambridge, England), 49(32), 3348-50. https://doi.org/10.1039/c3cc40432c

Kandioller, W, Balsano, E, Meier, SM, Jungwirth, U, Göschl, S, Roller, A, Jakupec, MA, Berger, W, Keppler, BK & Hartinger, CG 2013, 'Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity', Chemical communications (Cambridge, England), vol. 49, no. 32, pp. 3348-50. https://doi.org/10.1039/c3cc40432c

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abstract = "Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.",

keywords = "Amino Acids/chemistry, Antineoplastic Agents, Phytogenic/chemistry, Cell Line, Tumor, Cell Survival/drug effects, Coordination Complexes/chemistry, Guanine/analogs & derivatives, Humans, Naphthoquinones/chemistry, Osmium/chemistry, Reactive Oxygen Species/metabolism, Rhodium/chemistry, Ruthenium/chemistry",

author = "Wolfgang Kandioller and Evelyn Balsano and Meier, {Samuel M} and Ute Jungwirth and Simone G{\"o}schl and Alexander Roller and Jakupec, {Michael A} and Walter Berger and Keppler, {Bernhard K} and Hartinger, {Christian G}",

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doi = "10.1039/c3cc40432c",

language = "English",

volume = "49",

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journal = "Chemical communications (Cambridge, England)",

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T2 - metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

AU - Kandioller, Wolfgang

AU - Balsano, Evelyn

AU - Meier, Samuel M

AU - Jungwirth, Ute

AU - Göschl, Simone

AU - Roller, Alexander

AU - Jakupec, Michael A

AU - Berger, Walter

AU - Keppler, Bernhard K

AU - Hartinger, Christian G

PY - 2013/4/25

Y1 - 2013/4/25

N2 - Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

AB - Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

KW - Amino Acids/chemistry

KW - Antineoplastic Agents, Phytogenic/chemistry

KW - Cell Line, Tumor

KW - Cell Survival/drug effects

KW - Coordination Complexes/chemistry

KW - Guanine/analogs & derivatives

KW - Humans

KW - Naphthoquinones/chemistry

KW - Osmium/chemistry

KW - Reactive Oxygen Species/metabolism

KW - Rhodium/chemistry

KW - Ruthenium/chemistry

U2 - 10.1039/c3cc40432c

DO - 10.1039/c3cc40432c

M3 - Article

C2 - 23505633

SN - 1359-7345

VL - 49

SP - 3348

EP - 3350

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

IS - 32

ER -

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Abstract

Keywords

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