Optimizing residence time distribution in capillary-based systems using computational fluid dynamic simulations

Kirandeep K. Gill, Deema A. Masoudi, Sughan Narayanasamy, Patrick Hester, Pedro Estrela, Nuno M. Reis

Research output: Chapter or section in a book/report/conference proceedingChapter in a published conference proceeding

Abstract

Important features for flow chemistry systems are a narrow residence time distribution, appropriate sample volume and small pressure drop. These criteria were evaluated by studying hydrodynamic characteristics of tubular microflow systems using Computational Fluid Dynamics and experimental tracing breakthrough curves in a novel multi-bore Microcapillary Film Reactor (MFR). The inner diameter and diffusion coefficient of molecular species had a large influence on approaching ideal plug flow. Compared to a single large bore capillary (2400 µm i.d.), the MFR (363±32.2 µm) provides opportunity for improving product yields via excellent radial mixing whilst exhibiting all desired qualities for a high-performance flow system.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages1024-1025
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 7 Oct 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
Country/TerritorySwitzerland
CityBasel
Period27/10/1931/10/19

Keywords

  • Flow Reactor
  • Microcapillary Film Reactor
  • Residence time distribution
  • Tubular microflow

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

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