Optimal solid-state neurons

Kamal Abu Hassan, Joseph Taylor, Paul G Morris, Elisa Donati, Zuner A Bortolotto, Giacomo Indiveri, Julian Paton, Alain Nogaret

Research output: Contribution to journalArticle

Abstract

Bioelectronic medicine is driving the need for neuromorphic microcircuits that integrate raw nervous stimuli and respond identically to biological neurons. We realise this vision here by estimating the parameters of highly nonlinear conductance models and deriving the ab-initio equations of intracellular currents and membrane voltages embodied in analog solid-state electronics. By configuring individual ion channels of solid-state neurons with parameters estimated from large-scale assimilation of electrophysiological recordings, we successfully transferred the complete dynamics of hippocampal and respiratory neurons in-silico. The solid-state neurons were found to respond nearly identically to biological neurons under stimulation by a wide range of current injection protocols. The optimisation of nonlinear models demonstrates a powerful method for programming analog electronic circuits. This approach offers a route for repairing diseased biocircuits and emulating their function with biomedical implants that can adapt to biofeedback.
Original languageEnglish
JournalNature Communications
Publication statusAccepted/In press - 25 Sep 2019

Cite this

Abu Hassan, K., Taylor, J., Morris, P. G., Donati, E., Bortolotto, Z. A., Indiveri, G., ... Nogaret, A. (Accepted/In press). Optimal solid-state neurons. Nature Communications.

Optimal solid-state neurons. / Abu Hassan, Kamal; Taylor, Joseph; Morris, Paul G; Donati, Elisa; Bortolotto, Zuner A; Indiveri, Giacomo; Paton, Julian; Nogaret, Alain.

In: Nature Communications, 25.09.2019.

Research output: Contribution to journalArticle

Abu Hassan, K, Taylor, J, Morris, PG, Donati, E, Bortolotto, ZA, Indiveri, G, Paton, J & Nogaret, A 2019, 'Optimal solid-state neurons', Nature Communications.
Abu Hassan K, Taylor J, Morris PG, Donati E, Bortolotto ZA, Indiveri G et al. Optimal solid-state neurons. Nature Communications. 2019 Sep 25.
Abu Hassan, Kamal ; Taylor, Joseph ; Morris, Paul G ; Donati, Elisa ; Bortolotto, Zuner A ; Indiveri, Giacomo ; Paton, Julian ; Nogaret, Alain. / Optimal solid-state neurons. In: Nature Communications. 2019.
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