Optical Imaging Opportunities to Inspect the Nature of Cytosolic Iron Pools

Robert Charles Hider, Charareh Pourzand, Yongmin Ma, Agostino Cilibrizzi

Research output: Contribution to journalReview articlepeer-review

1 Citation (SciVal)

Abstract

The chemical nature of intracellular labile iron pools (LIPs) is described. By virtue of the kinetic lability of these pools, it is suggested that the isolation of such species by chromatography methods will not be possible, but rather mass spectrometric techniques should be adopted. Iron-sensitive fluorescent probes, which have been developed for the detection and quantification of LIP, are described, including those specifically designed to monitor cytosolic, mitochondrial, and lysosomal LIPs. The potential of near-infrared (NIR) probes for in vivo monitoring of LIP is discussed.
Original languageEnglish
Article number6467
Number of pages21
JournalMolecules
Volume28
Issue number18
Early online date6 Sept 2023
DOIs
Publication statusPublished - 6 Sept 2023

Keywords

  • fluorescence
  • imaging
  • iron sensitive optical probes
  • labile iron pools
  • near-infrared probes

ASJC Scopus subject areas

  • Drug Discovery
  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Physical and Theoretical Chemistry
  • Pharmaceutical Science
  • Organic Chemistry

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