Open questions: how to get developmental biology into shape?

Timothy E Saunders; Philip W Ingham

doi:10.1186/s12915-019-0636-6

Open questions: how to get developmental biology into shape?

Timothy E Saunders
, Philip W Ingham

Department of Life Sciences

National University of Singapore
Lee Kong Chian School of Medicine
Singapore Centre of Environmental Life Sciences Engineering (SCELSE) Nanyang Technological University
Institute of Molecular and Cell Biology (IMCB)
Living Systems Institute
University of Exeter

Research output: Contribution to journal › Article › peer-review

8 Citations (SciVal)

Abstract

Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shapes and sizes of organs remains unclear. Here, we outline major open questions in organogenesis and suggest how a synthesis between developmental biology and physics can help to address them.

Original language	English
Article number	17
Number of pages	3
Journal	BMC Biology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12915-019-0636-6
Publication status	Published - 22 Feb 2019

Keywords

Animals
Developmental Biology
Gene Expression Regulation, Developmental
Genome
Models, Biological
Organogenesis/physiology

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10.1186/s12915-019-0636-6Licence: CC BY

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title = "Open questions: how to get developmental biology into shape?",

abstract = "Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shapes and sizes of organs remains unclear. Here, we outline major open questions in organogenesis and suggest how a synthesis between developmental biology and physics can help to address them.",

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KW - Developmental Biology

KW - Gene Expression Regulation, Developmental

KW - Genome

KW - Models, Biological

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Open questions: how to get developmental biology into shape?

Abstract

Keywords

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