Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shapes and sizes of organs remains unclear. Here, we outline major open questions in organogenesis and suggest how a synthesis between developmental biology and physics can help to address them.

Original languageEnglish
Article number17
Number of pages3
JournalBMC Biology
Issue number1
Publication statusPublished - 22 Feb 2019


  • Animals
  • Developmental Biology
  • Gene Expression Regulation, Developmental
  • Genome
  • Models, Biological
  • Organogenesis/physiology


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