Ontogenesis of Hepatic and Pancreatic Stem Cells

Research output: Contribution to journalArticle

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Abstract

In the embryo, the liver and pancreas exhibit a close developmental relationship. Both tissues arise from neighbouring regions of the developing endoderm. As well as this close developmental relationship, the liver and pancreas can, under certain circumstances, regenerate functional components. Understanding the normal development of the two tissue types and the underlying cellular and molecular mechanisms governing normal development and regeneration is critical to the production of novel therapies for treating liver disease and pancreatic disorders such as diabetes and pancreatitis. Herein we discuss the development of the liver and pancreas from progenitor cells in the embryo and the existence of potential stem cells in the adult tissues.
LanguageEnglish
Pages586-596
JournalStem Cell Reviews and Reports
Volume8
Issue number2
DOIs
StatusPublished - 2012

Fingerprint

Pancreas
Stem Cells
Liver
Embryonic Structures
Endoderm
Adult Stem Cells
Pancreatitis
Liver Diseases
Regeneration
Therapeutics

Keywords

  • pancreas
  • stem cell
  • progenitor
  • liver
  • transdifferentiation

Cite this

Ontogenesis of Hepatic and Pancreatic Stem Cells. / Burke, Zoe D; Tosh, David.

In: Stem Cell Reviews and Reports, Vol. 8, No. 2, 2012, p. 586-596.

Research output: Contribution to journalArticle

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