Complex tripodal tris(2-aminoethyl)amine (tren)-based ligands have been prepared in a single-pot reaction of tren with 3 equiv each of cyclohexenone and a benzaldehyde derivative (i.e., from seven components and three molecular types). The highest yield of product was obtained for p-nitrobenzaldehyde, the most electrophilic aldehyde used.
Almesaker, A., Scott, J. L., Spiccia, L., & Strauss, C. R. (2009). One-pot synthesis of tripodal tris(2-aminoethyl)amine derivatives from seven molecular components. Tetrahedron Letters, 50(16), 1847-1850. https://doi.org/10.1016/j.tetlet.2009.02.008