Projects per year
Single-step synthetic protocols are reported for novel macrocyclic copper(ii) complexes incorporating a piperazine unit in the ligand backbone. Synchrotron X-ray structure determination confirmed the copper(ii) coordination geometry in the solid state as distorted square pyramidal with chloride occupying the axial position above the N4 ligand plane. DFT calculations, electrochemical studies and UV/vis investigations in biological media all confirmed that compounds in this class have high stability, and compare well in both thermodynamic and kinetic terms with the ubiquitous Cu(ii) cyclam compounds, and are therefore of relevance for future use as synthetic scaffolds for the binding, transport and tracing of copper ions in vitro.
|Number of pages||7|
|Early online date||6 Mar 2014|
|Publication status||Published - 6 Mar 2014|
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- 1 Finished
Fluorescence Lifetime Imaging of New Functional Biomaterials Invasive Early Tumour Diagnosis
Science and Technology Facilities Council
1/11/12 → 16/03/14
Project: Research council
High Performance Computing (HPC) Facility
Steven Chapman (Manager)University of Bath