One-pot synthesis, characterisation and kinetic stability of novel side-bridged pentaazamacrocyclic copper(ii) complexes

H.M. Betts, S I Pascu, A Buchard, P.D. Bonnitcha, J.R. Dilworth

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Single-step synthetic protocols are reported for novel macrocyclic copper(ii) complexes incorporating a piperazine unit in the ligand backbone. Synchrotron X-ray structure determination confirmed the copper(ii) coordination geometry in the solid state as distorted square pyramidal with chloride occupying the axial position above the N4 ligand plane. DFT calculations, electrochemical studies and UV/vis investigations in biological media all confirmed that compounds in this class have high stability, and compare well in both thermodynamic and kinetic terms with the ubiquitous Cu(ii) cyclam compounds, and are therefore of relevance for future use as synthetic scaffolds for the binding, transport and tracing of copper ions in vitro.
LanguageEnglish
Pages12964-12970
Number of pages7
JournalRSC Advances
Volume4
Issue number25
Early online date6 Mar 2014
DOIs
StatusPublished - 6 Mar 2014

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Copper
Kinetics
Ligands
Synchrotrons
Discrete Fourier transforms
Scaffolds
Chlorides
Thermodynamics
Ions
X rays
Geometry
cyclam
piperazine

Cite this

One-pot synthesis, characterisation and kinetic stability of novel side-bridged pentaazamacrocyclic copper(ii) complexes. / Betts, H.M.; Pascu, S I; Buchard, A; Bonnitcha, P.D.; Dilworth, J.R.

In: RSC Advances, Vol. 4, No. 25, 06.03.2014, p. 12964-12970.

Research output: Contribution to journalArticle

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