On the mathematical modelling of pain

N F Britton, S M Skevington

Research output: Contribution to journalArticlepeer-review

23 Citations (SciVal)


In this review a case is presented for the use of mathematical modelling in the study of pain. The philosophy of mathematical modelling is outlined and a recommendation is made for the use of modern nonlinear techniques and computational neuroscience in the modelling of pain. Classic and more recent examples of modelling in neurobiology in general and pain in particular, at three different levels-molecular, cellular and neural networks-are described and evaluated. Directions for further progress are indicated, particularly in plasticity and in modelling brain mechanisms. Major advantages of mathematical modelling are that it can handle extremely complex theories and it is non-invasive, and so is particularly valuable in the investigation of chronic pain.

Original languageEnglish
Pages (from-to)1133-40
Number of pages8
JournalNeurochemical Research
Issue number9
Publication statusPublished - Sept 1996


  • Analgesia
  • Animals
  • Axons
  • Humans
  • Models, Neurological
  • Models, Theoretical
  • Nerve Net
  • Neuronal Plasticity
  • Neurons
  • Pain
  • Reproducibility of Results


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