Memory B cells latently infected with Epstein-Barr virus (mB(Lats)) in the blood disappear rapidly on presentation with acute symptomatic primary infection (acute infectious mononucleosis [AIM]). They undergo a simple exponential decay (average half-life: 7.5 +/- 3.7 days) similar to that of normal memory B cells. The cytotoxic T lymphocyte (CTL) response to immediate early (IE) lytic antigens (CTL(IEs)) also decays over this time period, but no such correlation was observed for the CTL response to lytic or latent antigens or to the levels of virions shed into saliva. We have estimated the average half-life of CTL(IEs) to be 73 (+/- 23) days. We propose that cycles of infection and reactivation occur in the initial stages of infection that produce high levels of mB(Lats) in the circulation. Eventually the immune response arises and minimizes these cycles leaving the high levels of mB(Lats) in the blood to decay through simple memory B-cell homeostasis mechanisms. This triggers the cells to reactivate the virus whereupon most are killed by CTL(IEs) before they can release virus and infect new cells. The release of antigens caused by this large-scale destruction of infected cells may trigger the symptoms of AIM and be a cofactor in other AIM-associated diseases.
- Acute Disease Cell Proliferation Cytotoxicity, Immunologic/immunology Herpesvirus 4, Human/*immunology/*pathogenicity Immunologic Memory/immunology Infectious Mononucleosis/diagnosis/*immunology/*virology Time Factors
Hadinoto, V., Shapiro, M., Greenough, T. C., Sullivan, J. L., Luzuriaga, K., & Thorley-Lawson, D. A. (2008). On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood, 111(3), 1420-1427. https://doi.org/10.1182/blood-2007-06-093278 Collections Immunobiology and Immunotherapy Other Versions You are viewing the most current version of this article. blood-2007-06-093278v1 Email Alerts Citation Tools Cite This Powerpoint PDF Request Permissions Share Jump to Article Abstract Introduction Methods Results Discussion Authorship Acknowledgments Footnotes References Figures & Data Info & Metrics PDF Related Articles Erratum for Hadinoto et al. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood. 2008;111:1420-1427.