On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination

Endre J. Szili; Bhagirath Ghimire; Bethany Lee Patenall; Mohammed Rohaim; Dharmit Mistry; Adrian Fellows; Muhammad Munir; A. Toby A. Jenkins; Robert D. Short

doi:10.1063/5.0062787

On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination

Endre J. Szili, Bhagirath Ghimire, Bethany Lee Patenall, Mohammed Rohaim, Dharmit Mistry, Adrian Fellows, Muhammad Munir, A. Toby A. Jenkins, Robert D. Short

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

28 Citations (SciVal)

191 Downloads (Pure)

Abstract

Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for the "on-demand"activation of acetyl donor molecules. The process generates an aqueous-based antimicrobial formulation comprising a rich mixture of highly oxidizing molecules: peracetic acid, hydrogen peroxide, and other reactive oxygen and nitrogen species. The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2).

Original language	English
Article number	054104
Journal	Applied Physics Letters
Volume	119
Issue number	5
DOIs	https://doi.org/10.1063/5.0062787
Publication status	Published - 2 Aug 2021

Bibliographical note

Funding Information:
The authors would like to thank the EPSRC for funding on Grant Nos. EP/R003556/1 and EP/V00607X/1. E.J.S. acknowledges the support from the Australian Research Council Future Fellowship No. FT190100263, the National Health Medical Research Council Ideas Grant No. 2002510, and the Future Industries Accelerator Mobility Scheme MOB024.

Publisher Copyright:
© 2021 Author(s).

Funding

The authors would like to thank the EPSRC for funding on Grant Nos. EP/R003556/1 and EP/V00607X/1. E.J.S. acknowledges the support from the Australian Research Council Future Fellowship No. FT190100263, the National Health Medical Research Council Ideas Grant No. 2002510, and the Future Industries Accelerator Mobility Scheme MOB024.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

Access to Document

10.1063/5.0062787

5.0062787
2021 AIP Publishing Szili, EJ, Ghimire, B, Patenall, BL, Rohaim, M, Mistry, D, Fellows, A, Munir, M, Jenkins, ATA & Short, RD 2021, 'On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination', Applied Physics Letters, vol. 119, no. 5, 054104. https://doi.org/10.1063/5.0062787
Final published version, 1.16 MB

Cite this

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title = "On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination",

abstract = "Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for the {"}on-demand{"}activation of acetyl donor molecules. The process generates an aqueous-based antimicrobial formulation comprising a rich mixture of highly oxidizing molecules: peracetic acid, hydrogen peroxide, and other reactive oxygen and nitrogen species. The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2). ",

author = "Szili, \{Endre J.\} and Bhagirath Ghimire and Patenall, \{Bethany Lee\} and Mohammed Rohaim and Dharmit Mistry and Adrian Fellows and Muhammad Munir and Jenkins, \{A. Toby A.\} and Short, \{Robert D.\}",

note = "Funding Information: The authors would like to thank the EPSRC for funding on Grant Nos. EP/R003556/1 and EP/V00607X/1. E.J.S. acknowledges the support from the Australian Research Council Future Fellowship No. FT190100263, the National Health Medical Research Council Ideas Grant No. 2002510, and the Future Industries Accelerator Mobility Scheme MOB024. Publisher Copyright: {\textcopyright} 2021 Author(s).",

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doi = "10.1063/5.0062787",

language = "English",

volume = "119",

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T1 - On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination

AU - Szili, Endre J.

AU - Ghimire, Bhagirath

AU - Patenall, Bethany Lee

AU - Rohaim, Mohammed

AU - Mistry, Dharmit

AU - Fellows, Adrian

AU - Munir, Muhammad

AU - Jenkins, A. Toby A.

AU - Short, Robert D.

N1 - Funding Information: The authors would like to thank the EPSRC for funding on Grant Nos. EP/R003556/1 and EP/V00607X/1. E.J.S. acknowledges the support from the Australian Research Council Future Fellowship No. FT190100263, the National Health Medical Research Council Ideas Grant No. 2002510, and the Future Industries Accelerator Mobility Scheme MOB024. Publisher Copyright: © 2021 Author(s).

PY - 2021/8/2

Y1 - 2021/8/2

N2 - Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for the "on-demand"activation of acetyl donor molecules. The process generates an aqueous-based antimicrobial formulation comprising a rich mixture of highly oxidizing molecules: peracetic acid, hydrogen peroxide, and other reactive oxygen and nitrogen species. The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2).

AB - Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for the "on-demand"activation of acetyl donor molecules. The process generates an aqueous-based antimicrobial formulation comprising a rich mixture of highly oxidizing molecules: peracetic acid, hydrogen peroxide, and other reactive oxygen and nitrogen species. The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2).

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DO - 10.1063/5.0062787

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VL - 119

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 5

M1 - 054104

ER -

On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination

Abstract

Bibliographical note

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Plasma-activated antimicrobial hydrogel therapy (PAHT) for combating infections in diabetic foot ulcers - Bath-Lancaster-Glasgow project

Smartwound-plasma

Cite this

On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination

Abstract

Bibliographical note

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Plasma-activated antimicrobial hydrogel therapy (PAHT) for combating infections in diabetic foot ulcers - Bath-Lancaster-Glasgow project

Smartwound-plasma

Cite this