On-demand cold plasma activation of acetyl donors for bacteria and virus decontamination

Endre J. Szili, Bhagirath Ghimire, Bethany Lee Patenall, Mohammed Rohaim, Dharmit Mistry, Adrian Fellows, Muhammad Munir, A. Toby A. Jenkins, Robert D. Short

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17 Citations (SciVal)
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Antibiotics are commonly used as the first line of defense in the treatment of infectious diseases. However, the rise of antimicrobial resistance (AMR) is rendering many antibiotics less effective. Consequently, effective non-antibiotic antimicrobial strategies are urgently needed to combat AMR. This paper presents a strategy utilizing cold plasma for the "on-demand"activation of acetyl donor molecules. The process generates an aqueous-based antimicrobial formulation comprising a rich mixture of highly oxidizing molecules: peracetic acid, hydrogen peroxide, and other reactive oxygen and nitrogen species. The synergistic potent oxidative action between these molecules is shown to be highly effective at eradicating common wound pathogenic bacteria (Pseudomonas aeruginosa and Staphylococcus aureus) and at inactivating a virus (SARS-CoV-2).

Original languageEnglish
Article number054104
JournalApplied Physics Letters
Issue number5
Publication statusPublished - 2 Aug 2021

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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