On a new proposed mechanism of 5-fluorouracil-mediated cytotoxicity

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The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5 methyltransferase (U5MT), TRMT2A, and its interaction with 5-FU metabolites incorporated within tRNAs, lead to an additional hypothesis that is proposed here.
Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalTrends in Cancer
Issue number5
Early online date13 Mar 2020
Publication statusPublished - 1 May 2020


  • 5-fluorouracil
  • 5-methyluridine
  • DNA break repair
  • NUD1
  • RNA methylation
  • TRMT2A
  • homologous recombination

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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