Abstract
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5 methyltransferase (U5MT), TRMT2A, and its interaction with 5-FU metabolites incorporated within tRNAs, lead to an additional hypothesis that is proposed here.
Original language | English |
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Pages (from-to) | 365-368 |
Number of pages | 4 |
Journal | Trends in Cancer |
Volume | 6 |
Issue number | 5 |
Early online date | 13 Mar 2020 |
DOIs | |
Publication status | Published - 1 May 2020 |
Keywords
- 5-fluorouracil
- 5-methyluridine
- DNA break repair
- NUD1
- RNA methylation
- TRMT2A
- homologous recombination
ASJC Scopus subject areas
- Oncology
- Cancer Research