Oligomeric alpha-synuclein and its role in neuronal death

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Abstract

Alpha-synuclein is a natively unfolded protein associated with a number of neurodegenerative disorders that include Parkinson's disease. In the past, research has focused on the fibrillar form of the protein. Current research now indicates that oligomeric alpha-synuclein is the form of the protein most likely to causes neuronal death. Recent research has suggested that a unique oligomer associated with the copper binding capacity of the protein is the neurotoxic form of the protein. This review looks at the evidence for this possibility.
LanguageEnglish
Pages334-339
Number of pages6
JournalIUBMB Life
Volume62
Issue number5
DOIs
StatusPublished - 2010

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alpha-Synuclein
Research
Intrinsically Disordered Proteins
Proteins
Oligomers
Neurodegenerative Diseases
Parkinson Disease
Cause of Death

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Oligomeric alpha-synuclein and its role in neuronal death. / Brown, David R.

In: IUBMB Life, Vol. 62, No. 5, 2010, p. 334-339.

Research output: Contribution to journalArticle

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