Offering pregnant women different levels of genetic information from prenatal chromosome microarray: a prospective study

Jane L Halliday, Cecile Muller, Taryn Charles, Fiona Norris, Joanne Kennedy, Sharon Lewis, Bettina Meiser, Susan Donath, Zornitza Stark, George McGillivray, Melody Menezes, Sian K Smith, Della Forster, Susan Walker, Mark Pertile, David J Amor

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study aimed to examine the choice pregnant women make about the amount of fetal genetic information they want from chromosome microarray. Women having invasive prenatal testing in the absence of fetal structural abnormality were recruited in Victoria, Australia. A decision aid for women described 'targeted' analysis as reporting only copy number variants implicated in a highly penetrant and well-described phenotype and 'extended' as additionally reporting variants of uncertain or unknown significance. Participant's choice and demographics were collected by survey before chorionic villus sampling or amniocentesis; psychological data were also collected then and again about 10 days after receiving results. High-resolution single-nucleotide polymorphism array analysis was performed, and a clinical review committee assessed variants for reporting before returning results to participants. Sixty-six participants (59.5%) chose extended analysis and 45 (40.5%) targeted. Choosing extended information was associated with (1) indication for prenatal diagnosis: maternal age alone (adjusted odds ratio (adjOR) 9.6, 95% confidence interval (CI): 1.4-66.0, p= 0.02), or 'other' indication (adjOR 7.1, 95% CI: 1.5-33.1, p= 0.01)); (2) >12 months to conceive (adjOR 4.1, 95% CI: 1.0-17.7, p= 0.05); and (3) Asian background (adjOR 4.67, 95% CI: 1.0-21.0, p= 0.04). No adverse psychological impact occurred in either group. We conclude that offering pregnant women different levels of fetal genetic analysis is warranted, alongside decision support.

Original languageEnglish
Pages (from-to)485-494
Number of pages10
JournalEuropean Journal of Human Genetics
Volume26
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018

Keywords

  • Adult
  • Choice Behavior
  • Chromosome Disorders/diagnosis
  • Female
  • Genetic Testing/standards
  • Health Knowledge, Attitudes, Practice
  • Humans
  • Male
  • Pregnancy
  • Prenatal Diagnosis/psychology

Cite this

Offering pregnant women different levels of genetic information from prenatal chromosome microarray : a prospective study. / Halliday, Jane L; Muller, Cecile; Charles, Taryn; Norris, Fiona; Kennedy, Joanne; Lewis, Sharon; Meiser, Bettina; Donath, Susan; Stark, Zornitza; McGillivray, George; Menezes, Melody; Smith, Sian K; Forster, Della; Walker, Susan; Pertile, Mark; Amor, David J.

In: European Journal of Human Genetics, Vol. 26, No. 4, 01.04.2018, p. 485-494.

Research output: Contribution to journalArticle

Halliday, JL, Muller, C, Charles, T, Norris, F, Kennedy, J, Lewis, S, Meiser, B, Donath, S, Stark, Z, McGillivray, G, Menezes, M, Smith, SK, Forster, D, Walker, S, Pertile, M & Amor, DJ 2018, 'Offering pregnant women different levels of genetic information from prenatal chromosome microarray: a prospective study', European Journal of Human Genetics, vol. 26, no. 4, pp. 485-494. https://doi.org/10.1038/s41431-017-0084-0
Halliday, Jane L ; Muller, Cecile ; Charles, Taryn ; Norris, Fiona ; Kennedy, Joanne ; Lewis, Sharon ; Meiser, Bettina ; Donath, Susan ; Stark, Zornitza ; McGillivray, George ; Menezes, Melody ; Smith, Sian K ; Forster, Della ; Walker, Susan ; Pertile, Mark ; Amor, David J. / Offering pregnant women different levels of genetic information from prenatal chromosome microarray : a prospective study. In: European Journal of Human Genetics. 2018 ; Vol. 26, No. 4. pp. 485-494.
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abstract = "This study aimed to examine the choice pregnant women make about the amount of fetal genetic information they want from chromosome microarray. Women having invasive prenatal testing in the absence of fetal structural abnormality were recruited in Victoria, Australia. A decision aid for women described 'targeted' analysis as reporting only copy number variants implicated in a highly penetrant and well-described phenotype and 'extended' as additionally reporting variants of uncertain or unknown significance. Participant's choice and demographics were collected by survey before chorionic villus sampling or amniocentesis; psychological data were also collected then and again about 10 days after receiving results. High-resolution single-nucleotide polymorphism array analysis was performed, and a clinical review committee assessed variants for reporting before returning results to participants. Sixty-six participants (59.5{\%}) chose extended analysis and 45 (40.5{\%}) targeted. Choosing extended information was associated with (1) indication for prenatal diagnosis: maternal age alone (adjusted odds ratio (adjOR) 9.6, 95{\%} confidence interval (CI): 1.4-66.0, p= 0.02), or 'other' indication (adjOR 7.1, 95{\%} CI: 1.5-33.1, p= 0.01)); (2) >12 months to conceive (adjOR 4.1, 95{\%} CI: 1.0-17.7, p= 0.05); and (3) Asian background (adjOR 4.67, 95{\%} CI: 1.0-21.0, p= 0.04). No adverse psychological impact occurred in either group. We conclude that offering pregnant women different levels of fetal genetic analysis is warranted, alongside decision support.",
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