Nutrition for the ageing brain: towards evidence for an optimal diet

David Vauzour, Maria Camprubi-Robles,, Sophie Miquel-Kergoat, Christina Andres-Lacueva, Diana Banati, Pascale Barberger-Gateau, Gene Bowman, Laura Carbelotto, Robert Clarke, Eef Hogervorst, Amanda Kiliaan, Ugo Lucca, Claudine Manach, Anne-Marie Minihane, Ellen Siobhan Mitchell, Robert Perneczky, Hugh Perry, Anne-Marie Roussel, Jeroen Schuermans, John Sijben & 8 others Jeremy PE Spencer, Sandrine Thuret, Ondine van de Rest, Maurits Vandewoude, Keith Wesnes, Robert J Williams, Robin SB Williams, Maria Ramirez

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline.
Keywords: Cognition; preventive diet; cognitive decline; neuroprotection; neuroinflammation; cognitive
Original languageEnglish
Pages (from-to)222-240
JournalAgeing Research Reviews
Volume35
Early online date3 Oct 2016
DOIs
Publication statusPublished - 1 May 2017
EventILSI Europe: Nutrition for the Ageing Brain - Milan, Italy
Duration: 3 Jul 20144 Jul 2014

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Nutrition
Brain
Aging of materials
Diet
Cognition
Research
Biological Science Disciplines
Brain Diseases
Advisory Committees
Biomarkers
Nutrients
Maintenance
Food
Population
Cognitive Dysfunction

Keywords

  • Brain Ageing
  • Nutrition
  • Diet
  • Alzheimer Disease
  • Flavonoid
  • Cognition

Cite this

Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Banati, D., Barberger-Gateau, P., ... Ramirez, M. (2017). Nutrition for the ageing brain: towards evidence for an optimal diet. Ageing Research Reviews, 35, 222-240. https://doi.org/10.1016/j.arr.2016.09.010

Nutrition for the ageing brain: towards evidence for an optimal diet. / Vauzour, David; Camprubi-Robles, Maria; Miquel-Kergoat, Sophie; Andres-Lacueva, Christina; Banati, Diana; Barberger-Gateau, Pascale; Bowman, Gene; Carbelotto, Laura; Clarke, Robert; Hogervorst, Eef; Kiliaan, Amanda; Lucca, Ugo; Manach, Claudine; Minihane, Anne-Marie; Mitchell, Ellen Siobhan; Perneczky, Robert; Perry, Hugh; Roussel, Anne-Marie; Schuermans, Jeroen; Sijben, John; Spencer, Jeremy PE; Thuret, Sandrine; van de Rest, Ondine; Vandewoude, Maurits; Wesnes, Keith; Williams, Robert J; Williams, Robin SB; Ramirez, Maria.

In: Ageing Research Reviews, Vol. 35, 01.05.2017, p. 222-240.

Research output: Contribution to journalArticle

Vauzour, D, Camprubi-Robles, M, Miquel-Kergoat, S, Andres-Lacueva, C, Banati, D, Barberger-Gateau, P, Bowman, G, Carbelotto, L, Clarke, R, Hogervorst, E, Kiliaan, A, Lucca, U, Manach, C, Minihane, A-M, Mitchell, ES, Perneczky, R, Perry, H, Roussel, A-M, Schuermans, J, Sijben, J, Spencer, JPE, Thuret, S, van de Rest, O, Vandewoude, M, Wesnes, K, Williams, RJ, Williams, RSB & Ramirez, M 2017, 'Nutrition for the ageing brain: towards evidence for an optimal diet', Ageing Research Reviews, vol. 35, pp. 222-240. https://doi.org/10.1016/j.arr.2016.09.010
Vauzour D, Camprubi-Robles, M, Miquel-Kergoat S, Andres-Lacueva C, Banati D, Barberger-Gateau P et al. Nutrition for the ageing brain: towards evidence for an optimal diet. Ageing Research Reviews. 2017 May 1;35:222-240. https://doi.org/10.1016/j.arr.2016.09.010
Vauzour, David ; Camprubi-Robles, Maria ; Miquel-Kergoat, Sophie ; Andres-Lacueva, Christina ; Banati, Diana ; Barberger-Gateau, Pascale ; Bowman, Gene ; Carbelotto, Laura ; Clarke, Robert ; Hogervorst, Eef ; Kiliaan, Amanda ; Lucca, Ugo ; Manach, Claudine ; Minihane, Anne-Marie ; Mitchell, Ellen Siobhan ; Perneczky, Robert ; Perry, Hugh ; Roussel, Anne-Marie ; Schuermans, Jeroen ; Sijben, John ; Spencer, Jeremy PE ; Thuret, Sandrine ; van de Rest, Ondine ; Vandewoude, Maurits ; Wesnes, Keith ; Williams, Robert J ; Williams, Robin SB ; Ramirez, Maria. / Nutrition for the ageing brain: towards evidence for an optimal diet. In: Ageing Research Reviews. 2017 ; Vol. 35. pp. 222-240.
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