Nutrient sensing at the plasma membrane of fungal cells

Patrick Van Dijck, Neil Andrew Brown, Gustavo H. Goldman, Julian Rutherford, Chaoyang Xue, Griet Van Zeebroeck

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (SciVal)

Abstract

To respond to the changing environment, cells must be able to sense external conditions. This is important for many processes including growth, mating, the expression of virulence factors, and several other regulatory effects. Nutrient sensing at the plasma membrane is mediated by different classes of membrane proteins that activate downstream signaling pathways: nontransporting receptors, transceptors, classical and nonclassical G-protein-coupled receptors, and the newly defined extracellular mucin receptors. Nontransporting receptors have the same structure as transport proteins, but have lost the capacity to transport while gaining a receptor function. Transceptors are transporters that also function as a receptor, because they can rapidly activate downstream signaling pathways. In this review, we focus on these four types of fungal membrane proteins. We mainly discuss the sensing mechanisms relating to sugars, ammonium, and amino acids. Mechanisms for other nutrients, such as phosphate and sulfate, are discussed briefly. Because the model yeast Saccharomyces cerevisiae has been the most studied, especially regarding these nutrient-sensing systems, each subsection will commence with what is known in this species.

Original languageEnglish
Title of host publicationThe Fungal Kingdom
PublisherWiley
Pages419-439
Number of pages21
ISBN (Electronic)9781683670827
ISBN (Print)9781555819576
DOIs
Publication statusPublished - 5 Sep 2017

Keywords

  • Amino acid sensing
  • Carbon sensing
  • Extracellular mucin receptor
  • Fungal cell
  • G-protein-coupled receptor
  • Nontransporting receptors sensing glucose
  • Nontransporting receptors sensing nitrogen
  • Nutrient sensing
  • Plasma membrane
  • Transceptor-mediated ammonium sensing

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Fingerprint

Dive into the research topics of 'Nutrient sensing at the plasma membrane of fungal cells'. Together they form a unique fingerprint.

Cite this