NUMERICAL MODELLING OF LEUKOCYTE DEFORMATION IN VENTRICULAR ASSIST DEVICES

Katharine Fraser, Ina Laura Pieper

Research output: Contribution to conferenceAbstract

Abstract

Background: Despite the evolution of Ventricular Assist Devices (VADs), VAD
patients still suffer from complications, often due to damage to the blood
components by fluid dynamic stress. Damage to the leukocytes may contribute
to infections, one of the biggest post-surgical problems. In experiments
destruction of leukocytes was found to depend on impeller speed, flow rate
and the type of leukocyte.
Aim: The aim was to develop a numerical model for leukocyte deformation
to help explain differences in damage levels between VAD operating conditions
and between different cell types.
Methods: The cell was modelled as a spherical compound liquid drop with
concentric nucleus. The Navier- Stokes equations were solved using the finite
volume code OpenFOAM, with a Volume of Fluid method to calculate
fluid volume fractions. The surface tension of the fluids represented the
membranes. The effects of shear stress and elongational stress, on cells with
nuclei of different sizes, representing either neutrophils (small nucleus) or
lympohcytes (large nucleus), was investigated.
Results: Under both elongational and shear stress the cells with the smaller
nuclei deformed more than those with the larger nuclei. This could help to
explain why neutrophils are damaged more than lymphocytes in VADs.
Conclusions: A numerical model of leukocyte deformation has been created
and used to investigate cell deformation under elongational and shear stresses.
Original languageEnglish
Pages416 - 416
Number of pages1
DOIs
Publication statusPublished - 1 Sep 2017
Event44th ESAO and 7th IFAO Congress, 2017, Vienna - Vienna, Austria
Duration: 6 Sep 20179 Sep 2017

Conference

Conference44th ESAO and 7th IFAO Congress, 2017, Vienna
CountryAustria
CityVienna
Period6/09/179/09/17

Fingerprint

Heart-Assist Devices
Leukocytes
Neutrophils
Surface Tension
Hydrodynamics
Lymphocytes
Membranes
Infection

Cite this

Fraser, K., & Pieper, I. L. (2017). NUMERICAL MODELLING OF LEUKOCYTE DEFORMATION IN VENTRICULAR ASSIST DEVICES. 416 - 416. Abstract from 44th ESAO and 7th IFAO Congress, 2017, Vienna, Vienna, Austria. https://doi.org/10.5301/ijao.5000629

NUMERICAL MODELLING OF LEUKOCYTE DEFORMATION IN VENTRICULAR ASSIST DEVICES. / Fraser, Katharine; Pieper, Ina Laura.

2017. 416 - 416 Abstract from 44th ESAO and 7th IFAO Congress, 2017, Vienna, Vienna, Austria.

Research output: Contribution to conferenceAbstract

Fraser, K & Pieper, IL 2017, 'NUMERICAL MODELLING OF LEUKOCYTE DEFORMATION IN VENTRICULAR ASSIST DEVICES' 44th ESAO and 7th IFAO Congress, 2017, Vienna, Vienna, Austria, 6/09/17 - 9/09/17, pp. 416 - 416. https://doi.org/10.5301/ijao.5000629
Fraser K, Pieper IL. NUMERICAL MODELLING OF LEUKOCYTE DEFORMATION IN VENTRICULAR ASSIST DEVICES. 2017. Abstract from 44th ESAO and 7th IFAO Congress, 2017, Vienna, Vienna, Austria. https://doi.org/10.5301/ijao.5000629
Fraser, Katharine ; Pieper, Ina Laura. / NUMERICAL MODELLING OF LEUKOCYTE DEFORMATION IN VENTRICULAR ASSIST DEVICES. Abstract from 44th ESAO and 7th IFAO Congress, 2017, Vienna, Vienna, Austria.1 p.
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N2 - Background: Despite the evolution of Ventricular Assist Devices (VADs), VADpatients still suffer from complications, often due to damage to the bloodcomponents by fluid dynamic stress. Damage to the leukocytes may contributeto infections, one of the biggest post-surgical problems. In experimentsdestruction of leukocytes was found to depend on impeller speed, flow rateand the type of leukocyte.Aim: The aim was to develop a numerical model for leukocyte deformationto help explain differences in damage levels between VAD operating conditionsand between different cell types.Methods: The cell was modelled as a spherical compound liquid drop withconcentric nucleus. The Navier- Stokes equations were solved using the finitevolume code OpenFOAM, with a Volume of Fluid method to calculatefluid volume fractions. The surface tension of the fluids represented themembranes. The effects of shear stress and elongational stress, on cells withnuclei of different sizes, representing either neutrophils (small nucleus) orlympohcytes (large nucleus), was investigated.Results: Under both elongational and shear stress the cells with the smallernuclei deformed more than those with the larger nuclei. This could help toexplain why neutrophils are damaged more than lymphocytes in VADs.Conclusions: A numerical model of leukocyte deformation has been createdand used to investigate cell deformation under elongational and shear stresses.

AB - Background: Despite the evolution of Ventricular Assist Devices (VADs), VADpatients still suffer from complications, often due to damage to the bloodcomponents by fluid dynamic stress. Damage to the leukocytes may contributeto infections, one of the biggest post-surgical problems. In experimentsdestruction of leukocytes was found to depend on impeller speed, flow rateand the type of leukocyte.Aim: The aim was to develop a numerical model for leukocyte deformationto help explain differences in damage levels between VAD operating conditionsand between different cell types.Methods: The cell was modelled as a spherical compound liquid drop withconcentric nucleus. The Navier- Stokes equations were solved using the finitevolume code OpenFOAM, with a Volume of Fluid method to calculatefluid volume fractions. The surface tension of the fluids represented themembranes. The effects of shear stress and elongational stress, on cells withnuclei of different sizes, representing either neutrophils (small nucleus) orlympohcytes (large nucleus), was investigated.Results: Under both elongational and shear stress the cells with the smallernuclei deformed more than those with the larger nuclei. This could help toexplain why neutrophils are damaged more than lymphocytes in VADs.Conclusions: A numerical model of leukocyte deformation has been createdand used to investigate cell deformation under elongational and shear stresses.

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