Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug

Laury Trichard, M Begona Delgado-Charro, Richard H. Guy, Elias Fattal, Amelie Bochot

Research output: Contribution to journalArticle

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Abstract

Purpose. To investigate the potential of a novel lipid carrier, comprising beads of alpha-cyclodextrin and soybean oil, for topical drug delivery. Adapalene was chosen as a model drug to explore the ability of the beads to encapsulate and release a highly lipophilic compound. Materials and methods. Adapalene-loaded beads were prepared and characterised. Skin tolerance to unloaded beads was tested on human volunteers, while drug release and delivery into stratum corneum, was evaluated in pig skin ex vivo. Results. The preparation and physical characteristics of the beads were not dependent on whether adapalene had been previously dissolved or dispersed in soybean oil. Drug encapsulation efficiency was high (> 96%) and drug loading on the order of a therapeutic level could be achieved in freeze-dried beads prepared from an oily dispersion of adapalene. After application to human skin, unloaded beads induced no adverse reaction and were better tolerated than an alcoholic gel. Tape-stripping the stratum corneum from treated pig skin showed that adapalene release and penetration from the beads was comparable to that from gel and cream formulations available on the market. Conclusion. These novel beads may offer a well-tolerated and efficient system for the encapsulation and topical delivery of lipophilic drugs.
LanguageEnglish
Pages435-440
Number of pages6
JournalPharmaceutical Research
Volume25
Issue number2
DOIs
StatusPublished - Feb 2008

Fingerprint

Oils
Skin
Soybean Oil
Pharmaceutical Preparations
Encapsulation
Cornea
Swine
Gels
Drug delivery
Tapes
Volunteers
Adapalene
alpha-cyclodextrin
Lipids
Therapeutics

Keywords

  • Bead
  • Cyclodextrin
  • Topical formulation
  • Adapalene
  • Lipid carrier

Cite this

Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug. / Trichard, Laury; Delgado-Charro, M Begona; Guy, Richard H.; Fattal, Elias; Bochot, Amelie.

In: Pharmaceutical Research, Vol. 25, No. 2, 02.2008, p. 435-440.

Research output: Contribution to journalArticle

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