Novel Aryl and Heteroaryl Acyl Sulfamide Synthesis via Microwave-Assisted Palladium-Catalyzed Carbonylation

Bryan Roberts; David Liptrot; Lilian Alcaraz

doi:10.1021/ol100083w

Novel Aryl and Heteroaryl Acyl Sulfamide Synthesis via Microwave-Assisted Palladium-Catalyzed Carbonylation

Bryan Roberts
, David Liptrot
, Lilian Alcaraz

Department of Chemistry

AstraZeneca R&D Charnwood

Research output: Contribution to journal › Article › peer-review

18 Citations (SciVal)

Abstract

A novel, simple synthesis of aryl and heteroaryl acyl sulfamides has been developed via palladium-catalyzed carbonylation of aryl or heteroaryl halides in the presence of sulfamide nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation in a vessel equipped with a gas inlet adapter and proceeded in good to excellent yields.

Original language	English
Pages (from-to)	1264-1267
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	6
DOIs	https://doi.org/10.1021/ol100083w
Publication status	Published - 19 Mar 2010

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title = "Novel Aryl and Heteroaryl Acyl Sulfamide Synthesis via Microwave-Assisted Palladium-Catalyzed Carbonylation",

abstract = "A novel, simple synthesis of aryl and heteroaryl acyl sulfamides has been developed via palladium-catalyzed carbonylation of aryl or heteroaryl halides in the presence of sulfamide nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation in a vessel equipped with a gas inlet adapter and proceeded in good to excellent yields.",

author = "Bryan Roberts and David Liptrot and Lilian Alcaraz",

year = "2010",

month = mar,

day = "19",

doi = "10.1021/ol100083w",

language = "English",

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journal = "Organic Letters",

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T1 - Novel Aryl and Heteroaryl Acyl Sulfamide Synthesis via Microwave-Assisted Palladium-Catalyzed Carbonylation

AU - Roberts, Bryan

AU - Liptrot, David

AU - Alcaraz, Lilian

PY - 2010/3/19

Y1 - 2010/3/19

N2 - A novel, simple synthesis of aryl and heteroaryl acyl sulfamides has been developed via palladium-catalyzed carbonylation of aryl or heteroaryl halides in the presence of sulfamide nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation in a vessel equipped with a gas inlet adapter and proceeded in good to excellent yields.

AB - A novel, simple synthesis of aryl and heteroaryl acyl sulfamides has been developed via palladium-catalyzed carbonylation of aryl or heteroaryl halides in the presence of sulfamide nucleophiles. A range of reactions illustrating the wide scope of this reaction was carried out under microwave irradiation in a vessel equipped with a gas inlet adapter and proceeded in good to excellent yields.

U2 - 10.1021/ol100083w

DO - 10.1021/ol100083w

M3 - Article

SN - 1523-7060

VL - 12

SP - 1264

EP - 1267

JO - Organic Letters

JF - Organic Letters

IS - 6

ER -

Novel Aryl and Heteroaryl Acyl Sulfamide Synthesis via Microwave-Assisted Palladium-Catalyzed Carbonylation

Abstract

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