Novel applications for staphylococcus aureus SBI protein

Research output: Patent


The invention relates to the Sbi protein of Staphylococcus aureus. It has been found that Sbi can bind to the C3 complement protein and various proteolytic fragments thereof and consequently is able to inhibit the three complement pathways (i.e. the classical pathway, the alternative pathway and the lectin pathway). The invention therefore provides methods and compositions for inhibition of the complement system and for treatment of inflammatory conditions characterised by undesirable activation of the complement pathway.
Original languageEnglish
Patent numberW02007138328(A2)
Priority date31/05/06
Filing date31/05/07
Publication statusPublished - 6 Dec 2007


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