Novel and versatile synthesis of disubstituted 1,2-dihydro-1,2,4-triazol-3-ones

Mark A Graham, Paul A Bethel, Jonathan Burgess, Gary Fairley, Steve C Glossop, Ryan D R Greenwood, Clifford D Jones, Scott Lovell, Steve Swallow

Research output: Contribution to journalArticlepeer-review

5 Citations (SciVal)


A novel method for the synthesis of a wide range of 1,5-disubstituted 1,2-dihydro-1,2,4-triazol-3-ones is described. The key step involves a reaction between a dilithiated BOC-hydrazine and a N-alkoxycarbonylcarboximidothioate. A broad range of aryl and alkyl functional groups are tolerated, providing a versatile route for the synthesis of triazolones.

Original languageEnglish
Pages (from-to)6078-81
Number of pages4
JournalOrganic letters
Issue number23
Early online date18 Nov 2013
Publication statusPublished - 6 Dec 2013


  • Lithium/chemistry
  • Molecular Structure
  • Organometallic Compounds/chemistry
  • Triazoles/chemical synthesis


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