Notch is required for outgrowth of the Xenopus tail bud

C W Beck, J M W Slack

Research output: Contribution to journalArticlepeer-review

32 Citations (SciVal)


It has previously been shown that Notch, Delta and Lunatic Fringe are expressed together in the leading edge of the tail bud of the Xenopus embryo prior to outgrowth (Beck and Slack, 1998). It has also been shown that ectopic expression of a constitutive form of Notch, Notch-ICD, will provoke ectopic tail formation (Beck and Slack, 1999). Here we show that inhibition of Notch activity in vivo prevents outgrowth of the tail bud. This is achieved using inhibitors of the protease that carries out the ligand-induced intramembranous cleavage of Notch. Other protease inhibitors that do not inhibit Notch cleavage do not affect tail outgrowth.
Original languageEnglish
Pages (from-to)255-258
Number of pages4
JournalInternational Journal of Developmental Biology
Issue number2
Publication statusPublished - 2002

Bibliographical note

ID number: ISI:000174671100007


Dive into the research topics of 'Notch is required for outgrowth of the Xenopus tail bud'. Together they form a unique fingerprint.

Cite this