Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism

Ashraf M A. Qasem, Ziyu Zeng, Michael G. Rowan, Ian S. Blagbrough

Research output: Contribution to journalArticlepeer-review

Abstract

Covering: 77 A.D. up to 2020 Norditerpenoid alkaloids (NDA), typically N-ethylpiperidine containing C19 or C18 natural product diterpenes, are hexacycles with several contiguous often oxygenated stereocentres. As a function of their structural complexity, they display important pharmacological activities. The processed plants are used as important folk drugs and four NDAs have now been clinically approved. Many metabolism studies on Aconitum alkaloids have been reported as the understanding of their biotransformation in living systems and in cell-free systems is important for the development of these alkaloids as drugs. This Highlight sets out the missing links in NDA biosynthesis, their biological applications, SAR, toxicity, metabolism, and analytical studies.

Original languageEnglish
Pages (from-to)460-473
Number of pages14
JournalNatural Product Reports
Volume39
Issue number3
Early online date12 Oct 2021
DOIs
Publication statusPublished - 1 Mar 2022

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism'. Together they form a unique fingerprint.

Cite this