Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism

Ashraf M A. Qasem; Ziyu Zeng; Michael G. Rowan; Ian S. Blagbrough

doi:10.1039/d1np00029b

Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism

Ashraf M A. Qasem, Ziyu Zeng, Michael G. Rowan, Ian S. Blagbrough

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

28 Citations (SciVal)

Abstract

Covering: 77 A.D. up to 2020 Norditerpenoid alkaloids (NDA), typically N-ethylpiperidine containing C19 or C18 natural product diterpenes, are hexacycles with several contiguous often oxygenated stereocentres. As a function of their structural complexity, they display important pharmacological activities. The processed plants are used as important folk drugs and four NDAs have now been clinically approved. Many metabolism studies on Aconitum alkaloids have been reported as the understanding of their biotransformation in living systems and in cell-free systems is important for the development of these alkaloids as drugs. This Highlight sets out the missing links in NDA biosynthesis, their biological applications, SAR, toxicity, metabolism, and analytical studies.

Original language	English
Pages (from-to)	460-473
Number of pages	14
Journal	Natural Product Reports
Volume	39
Issue number	3
Early online date	12 Oct 2021
DOIs	https://doi.org/10.1039/d1np00029b
Publication status	Published - 1 Mar 2022

Bibliographical note

Funding Information:
We thank Zarqa University, Jordan, for the Studentship to Ashraf M. A. Qasem. We thank the University of Bath for the partial support of Dr Ziyu Zeng.

Funding

We thank Zarqa University, Jordan, for the Studentship to Ashraf M. A. Qasem. We thank the University of Bath for the partial support of Dr Ziyu Zeng.

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1039/d1np00029bLicence: CC BY

Cite this

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abstract = "Covering: 77 A.D. up to 2020 Norditerpenoid alkaloids (NDA), typically N-ethylpiperidine containing C19 or C18 natural product diterpenes, are hexacycles with several contiguous often oxygenated stereocentres. As a function of their structural complexity, they display important pharmacological activities. The processed plants are used as important folk drugs and four NDAs have now been clinically approved. Many metabolism studies on Aconitum alkaloids have been reported as the understanding of their biotransformation in living systems and in cell-free systems is important for the development of these alkaloids as drugs. This Highlight sets out the missing links in NDA biosynthesis, their biological applications, SAR, toxicity, metabolism, and analytical studies.",

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Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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