Abstract
Solutions of the Lewis acid B(C6F5)3 in 1,4-dioxane are found to effectively catalyze the hydrogenation of a variety of ketones and aldehydes. These reactions, the first to allow entirely metal-free catalytic hydrogenation of carbonyl groups under relatively mild reaction conditions, are found to proceed via a “frustrated Lewis pair” mechanism in which the solvent, a weak Brønsted base yet moderately strong donor, plays a pivotal role.
Original language | English |
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Pages (from-to) | 15813–15816 |
Journal | Journal of the American Chemical Society |
Volume | 136 |
Issue number | 45 |
DOIs | |
Publication status | Published - 21 Oct 2014 |