Nonmetal Catalyzed Hydrogenation of Carbonyl Compounds

Daniel Scott, Matthew J. Fuchter, Andrew Ashley

Research output: Contribution to journalArticlepeer-review

205 Citations (SciVal)

Abstract

Solutions of the Lewis acid B(C6F5)3 in 1,4-dioxane are found to effectively catalyze the hydrogenation of a variety of ketones and aldehydes. These reactions, the first to allow entirely metal-free catalytic hydrogenation of carbonyl groups under relatively mild reaction conditions, are found to proceed via a “frustrated Lewis pair” mechanism in which the solvent, a weak Brønsted base yet moderately strong donor, plays a pivotal role.
Original languageEnglish
Pages (from-to)15813–15816
JournalJournal of the American Chemical Society
Volume136
Issue number45
DOIs
Publication statusPublished - 21 Oct 2014

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