Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform

Luca Lipani, Bertrand G. R. Dupont, Floriant Doungmene, Frank Marken, Rex M. Tyrrell, Richard H. Guy, Adelina Ilie

Research output: Contribution to journalArticle

Abstract

Currently, there is no available needle-free approach for diabetics to monitor glucose levels in the interstitial fluid. Here, we report a path-selective, non-invasive, transdermal glucose monitoring system based on a miniaturized pixel array platform (realized either by graphene-based thin-film technology, or screen-printing). The system samples glucose from the interstitial fluid via electroosmotic extraction through individual, privileged, follicular pathways in the skin, accessible via the pixels of the array. A proof of principle using mammalian skin ex vivo is demonstrated for specific and ‘quantized’ glucose extraction/detection via follicular pathways, and across the hypo- to hyper-glycaemic range in humans. Furthermore, the quantification of follicular and non-follicular glucose extraction fluxes is clearly shown. In vivo continuous monitoring of interstitial fluid-borne glucose with the pixel array was able to track blood sugar in healthy human subjects. This approach paves the way to clinically relevant glucose detection in diabetics without the need for invasive, finger-stick blood sampling.
Original languageEnglish
JournalNature Nanotechnology
Early online date9 Apr 2018
DOIs
StateE-pub ahead of print - 9 Apr 2018

Fingerprint

glucose
Glucose
Antimony Potassium Tartrate
Pectoralis Muscles
Amoxicillin
interstitials
Pixels
pixels
Acyclic Acids
Graphene
blood
Fluids
Nitrobenzenes
Monitoring
fluids
Skin
graphene
Blood
platforms
Beta-Globulins

Keywords

  • glucose monitoring
  • transdermal
  • Iontophoresis
  • non-invasive sampling
  • graphene

Cite this

@article{1b528c8c4fd74cd69f945f04e5f6c29c,
title = "Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform",
abstract = "Currently, there is no available needle-free approach for diabetics to monitor glucose levels in the interstitial fluid. Here, we report a path-selective, non-invasive, transdermal glucose monitoring system based on a miniaturized pixel array platform (realized either by graphene-based thin-film technology, or screen-printing). The system samples glucose from the interstitial fluid via electroosmotic extraction through individual, privileged, follicular pathways in the skin, accessible via the pixels of the array. A proof of principle using mammalian skin ex vivo is demonstrated for specific and ‘quantized’ glucose extraction/detection via follicular pathways, and across the hypo- to hyper-glycaemic range in humans. Furthermore, the quantification of follicular and non-follicular glucose extraction fluxes is clearly shown. In vivo continuous monitoring of interstitial fluid-borne glucose with the pixel array was able to track blood sugar in healthy human subjects. This approach paves the way to clinically relevant glucose detection in diabetics without the need for invasive, finger-stick blood sampling.",
keywords = "glucose monitoring, transdermal, Iontophoresis, non-invasive sampling, graphene",
author = "Luca Lipani and Dupont, {Bertrand G. R.} and Floriant Doungmene and Frank Marken and Tyrrell, {Rex M.} and Guy, {Richard H.} and Adelina Ilie",
year = "2018",
month = "4",
doi = "10.1038/s41565-018-0112-4",
journal = "Nature Nanotechnology",
issn = "1748-3387",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform

AU - Lipani,Luca

AU - Dupont,Bertrand G. R.

AU - Doungmene,Floriant

AU - Marken,Frank

AU - Tyrrell,Rex M.

AU - Guy,Richard H.

AU - Ilie,Adelina

PY - 2018/4/9

Y1 - 2018/4/9

N2 - Currently, there is no available needle-free approach for diabetics to monitor glucose levels in the interstitial fluid. Here, we report a path-selective, non-invasive, transdermal glucose monitoring system based on a miniaturized pixel array platform (realized either by graphene-based thin-film technology, or screen-printing). The system samples glucose from the interstitial fluid via electroosmotic extraction through individual, privileged, follicular pathways in the skin, accessible via the pixels of the array. A proof of principle using mammalian skin ex vivo is demonstrated for specific and ‘quantized’ glucose extraction/detection via follicular pathways, and across the hypo- to hyper-glycaemic range in humans. Furthermore, the quantification of follicular and non-follicular glucose extraction fluxes is clearly shown. In vivo continuous monitoring of interstitial fluid-borne glucose with the pixel array was able to track blood sugar in healthy human subjects. This approach paves the way to clinically relevant glucose detection in diabetics without the need for invasive, finger-stick blood sampling.

AB - Currently, there is no available needle-free approach for diabetics to monitor glucose levels in the interstitial fluid. Here, we report a path-selective, non-invasive, transdermal glucose monitoring system based on a miniaturized pixel array platform (realized either by graphene-based thin-film technology, or screen-printing). The system samples glucose from the interstitial fluid via electroosmotic extraction through individual, privileged, follicular pathways in the skin, accessible via the pixels of the array. A proof of principle using mammalian skin ex vivo is demonstrated for specific and ‘quantized’ glucose extraction/detection via follicular pathways, and across the hypo- to hyper-glycaemic range in humans. Furthermore, the quantification of follicular and non-follicular glucose extraction fluxes is clearly shown. In vivo continuous monitoring of interstitial fluid-borne glucose with the pixel array was able to track blood sugar in healthy human subjects. This approach paves the way to clinically relevant glucose detection in diabetics without the need for invasive, finger-stick blood sampling.

KW - glucose monitoring

KW - transdermal

KW - Iontophoresis

KW - non-invasive sampling

KW - graphene

U2 - 10.1038/s41565-018-0112-4

DO - 10.1038/s41565-018-0112-4

M3 - Article

JO - Nature Nanotechnology

T2 - Nature Nanotechnology

JF - Nature Nanotechnology

SN - 1748-3387

ER -