Noise-induced metastability in biochemical networks

Tommaso Biancalani, Tim Rogers, Alan J. McKane

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Intra-cellular biochemical reactions exhibit a rich dynamical phenomenology which cannot be explained within the framework of mean-field rate equations and additive noise. Here, we show that the presence of metastable states and radically different timescales are general features of a broad class of autocatalyic reaction networks, and moreover, that this fact may be exploited to gain analytical results. The latter point is demonstrated by a treatment of the paradigmatic Togashi-Kaneko reaction, which has resisted theoretical analysis for the last decade.
Original languageEnglish
Article number010106(R)
Number of pages4
JournalPhysical Review E
Volume86
Issue number1
DOIs
Publication statusPublished - 2012

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