TY - JOUR
T1 - Nicotinic acetylcholine receptors and the regulation of neuronal signalling
AU - Dajas-Bailador, F
AU - Wonnacott, S
PY - 2004/6
Y1 - 2004/6
N2 - Neuronal nicotinic acetylcholine (nACh) receptors in the brain are more commonly associated with modulatory events than mediation of synaptic transmission. nACh receptors have a high permeability for Ca2+, and Ca2+ signals are pivotal in shaping nACh receptor-mediated neuromodulatory effects. In this review, we consider the mechanisms through which nACh receptors convert rapid ionic signals into sustained, wide-ranging phenomena. The complex Ca2+ responses that are generated after activation of nACh receptors can transmit information beyond the initial domain and facilitate the interface with many intracellular processes. These mechanisms underlie the diverse repertoire of neuronal activities of nicotine in the brain, from the enhancement of learning and memory, to addiction and neuroprotection.
AB - Neuronal nicotinic acetylcholine (nACh) receptors in the brain are more commonly associated with modulatory events than mediation of synaptic transmission. nACh receptors have a high permeability for Ca2+, and Ca2+ signals are pivotal in shaping nACh receptor-mediated neuromodulatory effects. In this review, we consider the mechanisms through which nACh receptors convert rapid ionic signals into sustained, wide-ranging phenomena. The complex Ca2+ responses that are generated after activation of nACh receptors can transmit information beyond the initial domain and facilitate the interface with many intracellular processes. These mechanisms underlie the diverse repertoire of neuronal activities of nicotine in the brain, from the enhancement of learning and memory, to addiction and neuroprotection.
UR - http://dx.doi.org/10.1016/j.tips.2004.04.006
U2 - 10.1016/j.tips.2004.04.006
DO - 10.1016/j.tips.2004.04.006
M3 - Article
SN - 0165-6147
VL - 25
SP - 317
EP - 324
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 6
ER -