New sources of β-cells for treating diabetes

S Saha, David Tosh, A A Hardikar

Research output: Contribution to journalArticlepeer-review

24 Citations (SciVal)


The treatment of diabetes by islet transplantation is presently hampered by the shortage of organ donors. The generation of insulin-producing cells is therefore a major objective in the long-term goal Of curing diabetes. Alternative Sources of pancreatic beta-cells include existing pancreatic cells, embryonic stern cells, and cells from other tissues such as liver. This commentary considers evidence for two new sources of beta-cells: intrahepatic biliary epithelial cells and gall bladder epithelium. These observations raise the possibility that a patient's,, own cells may be used as a source of insulin-producing cells for cell replacement in diabetes
Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalJournal of Endocrinology
Issue number1
Publication statusPublished - Jul 2009


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