New developments in the biomedical chemistry of metal complexes: from small molecules to nanotheranostic design

Rory L Arrowsmith, Sofia I Pascu, Hubert Jakub Smugowski

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

Recent advancements in bioimaging involving metal complexes with a focus on organometallic and coordination complexes are discussed with the aim to highlight their applications towards a new era in diagnostics: personalised medicine. The use of small molecules encapsulated within or attached to nanostructures for multimodal imaging and/or theranostic applications will be also discussed. Probes for imaging methods such as luminescence, PET, SPECT and MRI will be included as each modality possessing its own advantages and limitations. The current drive towards combination of techniques which will lead to complementary information on processes in cells and tissues and a more accurate, earlier diagnosis of tumours will also be discussed. The possibility of simultaneous diagnosis and therapy draws closer the advancement of probes from ‘bench to bedside’ and will be underlined in this review.
LanguageEnglish
Title of host publicationOrganometallic Chemistry
Place of PublicationCambridge
PublisherRSC
ISBN (Print)9781849734868
DOIs
StatusPublished - 2012

Publication series

NameOrganometallic Chemistry
Volume38

Fingerprint

Coordination Complexes
Imaging techniques
Molecules
Organometallics
Magnetic resonance imaging
Medicine
Luminescence
Tumors
Nanostructures
Tissue

Cite this

Arrowsmith, R. L., Pascu, S. I., & Smugowski, H. J. (2012). New developments in the biomedical chemistry of metal complexes: from small molecules to nanotheranostic design. In Organometallic Chemistry (Organometallic Chemistry; Vol. 38). Cambridge: RSC. https://doi.org/10.1039/9781849734868-00001

New developments in the biomedical chemistry of metal complexes : from small molecules to nanotheranostic design. / Arrowsmith, Rory L; Pascu, Sofia I; Smugowski, Hubert Jakub.

Organometallic Chemistry. Cambridge : RSC, 2012. (Organometallic Chemistry; Vol. 38).

Research output: Chapter in Book/Report/Conference proceedingChapter

Arrowsmith, RL, Pascu, SI & Smugowski, HJ 2012, New developments in the biomedical chemistry of metal complexes: from small molecules to nanotheranostic design. in Organometallic Chemistry. Organometallic Chemistry, vol. 38, RSC, Cambridge. https://doi.org/10.1039/9781849734868-00001
Arrowsmith RL, Pascu SI, Smugowski HJ. New developments in the biomedical chemistry of metal complexes: from small molecules to nanotheranostic design. In Organometallic Chemistry. Cambridge: RSC. 2012. (Organometallic Chemistry). https://doi.org/10.1039/9781849734868-00001
Arrowsmith, Rory L ; Pascu, Sofia I ; Smugowski, Hubert Jakub. / New developments in the biomedical chemistry of metal complexes : from small molecules to nanotheranostic design. Organometallic Chemistry. Cambridge : RSC, 2012. (Organometallic Chemistry).
@inbook{68904e7ba1064739a32efdd7426543d2,
title = "New developments in the biomedical chemistry of metal complexes: from small molecules to nanotheranostic design",
abstract = "Recent advancements in bioimaging involving metal complexes with a focus on organometallic and coordination complexes are discussed with the aim to highlight their applications towards a new era in diagnostics: personalised medicine. The use of small molecules encapsulated within or attached to nanostructures for multimodal imaging and/or theranostic applications will be also discussed. Probes for imaging methods such as luminescence, PET, SPECT and MRI will be included as each modality possessing its own advantages and limitations. The current drive towards combination of techniques which will lead to complementary information on processes in cells and tissues and a more accurate, earlier diagnosis of tumours will also be discussed. The possibility of simultaneous diagnosis and therapy draws closer the advancement of probes from ‘bench to bedside’ and will be underlined in this review.",
author = "Arrowsmith, {Rory L} and Pascu, {Sofia I} and Smugowski, {Hubert Jakub}",
year = "2012",
doi = "10.1039/9781849734868-00001",
language = "English",
isbn = "9781849734868",
series = "Organometallic Chemistry",
publisher = "RSC",
booktitle = "Organometallic Chemistry",

}

TY - CHAP

T1 - New developments in the biomedical chemistry of metal complexes

T2 - from small molecules to nanotheranostic design

AU - Arrowsmith, Rory L

AU - Pascu, Sofia I

AU - Smugowski, Hubert Jakub

PY - 2012

Y1 - 2012

N2 - Recent advancements in bioimaging involving metal complexes with a focus on organometallic and coordination complexes are discussed with the aim to highlight their applications towards a new era in diagnostics: personalised medicine. The use of small molecules encapsulated within or attached to nanostructures for multimodal imaging and/or theranostic applications will be also discussed. Probes for imaging methods such as luminescence, PET, SPECT and MRI will be included as each modality possessing its own advantages and limitations. The current drive towards combination of techniques which will lead to complementary information on processes in cells and tissues and a more accurate, earlier diagnosis of tumours will also be discussed. The possibility of simultaneous diagnosis and therapy draws closer the advancement of probes from ‘bench to bedside’ and will be underlined in this review.

AB - Recent advancements in bioimaging involving metal complexes with a focus on organometallic and coordination complexes are discussed with the aim to highlight their applications towards a new era in diagnostics: personalised medicine. The use of small molecules encapsulated within or attached to nanostructures for multimodal imaging and/or theranostic applications will be also discussed. Probes for imaging methods such as luminescence, PET, SPECT and MRI will be included as each modality possessing its own advantages and limitations. The current drive towards combination of techniques which will lead to complementary information on processes in cells and tissues and a more accurate, earlier diagnosis of tumours will also be discussed. The possibility of simultaneous diagnosis and therapy draws closer the advancement of probes from ‘bench to bedside’ and will be underlined in this review.

UR - http://dx.doi.org/10.1039/9781849734868-00001

U2 - 10.1039/9781849734868-00001

DO - 10.1039/9781849734868-00001

M3 - Chapter

SN - 9781849734868

T3 - Organometallic Chemistry

BT - Organometallic Chemistry

PB - RSC

CY - Cambridge

ER -