Neuroticism Response to Stress, Genetic Mapping of Mice

M. R. Munafò; J. Flint

doi:10.1016/B978-012373947-6.00585-7

Neuroticism Response to Stress, Genetic Mapping of Mice

M. R. Munafò, J. Flint

Vice Chancellor's Office

University of Bristol

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

Abstract

Broad personality traits that underlie individual differences in response to stress and vulnerability to anxiety and depression in humans have been known for some time to have a genetic basis. These traits have been described variously in humans as neuroticism, trait anxiety, and harm avoidance. Animal models of emotionality offer the opportunity to investigate the genetic basis of these traits with a greater degree of experimental control than in human studies and thereby to better understand the genetic etiology of emotionality. Recently, evidence for an overlap between the genetic basis for emotionality in rodent models and trait neuroticism in humans has emerged, which may help determine whether there is a common set of genes that contribute to trait neuroticism in humans and analog models of emotionality in animals. © 2007

Original language	English
Title of host publication	Encyclopedia of Stress
Publisher	Elsevier Academic Press Inc
Pages	914-917
Number of pages	4
ISBN (Print)	9780123739476
DOIs	https://doi.org/10.1016/B978-012373947-6.00585-7
Publication status	Published - 30 Sept 2007

ASJC Scopus subject areas

General Neuroscience
General Psychology

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10.1016/B978-012373947-6.00585-7

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AB - Broad personality traits that underlie individual differences in response to stress and vulnerability to anxiety and depression in humans have been known for some time to have a genetic basis. These traits have been described variously in humans as neuroticism, trait anxiety, and harm avoidance. Animal models of emotionality offer the opportunity to investigate the genetic basis of these traits with a greater degree of experimental control than in human studies and thereby to better understand the genetic etiology of emotionality. Recently, evidence for an overlap between the genetic basis for emotionality in rodent models and trait neuroticism in humans has emerged, which may help determine whether there is a common set of genes that contribute to trait neuroticism in humans and analog models of emotionality in animals. © 2007

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BT - Encyclopedia of Stress

PB - Elsevier Academic Press Inc

ER -

Neuroticism Response to Stress, Genetic Mapping of Mice

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