Neuropathic pain

Luana Colloca, Taylor Ludman, Didier Bouhassira, Ralf Baron, Anthony H. Dickenson, David Yarnitsky, Roy Freeman, Andrea Truini, Nadine Attal, Nanna B. Finnerup, Christopher Eccleston, Eija Kalso, David L. Bennett, Robert H. Dworkin, Srinivasa N. Raja

Research output: Contribution to journalArticle

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Abstract

Neuropathic pain is caused by a lesion or disease of the somatosensory system, including peripheral fibres (Aβ, AÎ and C fibres) and central neurons, and affects 7-10% of the general population. Multiple causes of neuropathic pain have been described and its incidence is likely to increase owing to the ageing global population, increased incidence of diabetes mellitus and improved survival from cancer after chemotherapy. Indeed, imbalances between excitatory and inhibitory somatosensory signalling, alterations in ion channels and variability in the way that pain messages are modulated in the central nervous system all have been implicated in neuropathic pain. The burden of chronic neuropathic pain seems to be related to the complexity of neuropathic symptoms, poor outcomes and difficult treatment decisions. Importantly, quality of life is impaired in patients with neuropathic pain owing to increased drug prescriptions and visits to health care providers, as well as the morbidity from the pain itself and the inciting disease. Despite challenges, progress in the understanding of the pathophysiology of neuropathic pain is spurring the development of new diagnostic procedures and personalized interventions, which emphasize the need for a multidisciplinary approach to the management of neuropathic pain.

LanguageEnglish
Article number17002
JournalNature Reviews Disease Primers
Volume3
DOIs
StatusPublished - 16 Feb 2017

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Neuralgia
Drug Prescriptions
Pain
Unmyelinated Nerve Fibers
Incidence
Ion Channels
Chronic Pain
Health Personnel
Population
Diabetes Mellitus
Central Nervous System
Quality of Life
Morbidity
Neurons
Drug Therapy
Survival
Neoplasms

Cite this

Colloca, L., Ludman, T., Bouhassira, D., Baron, R., Dickenson, A. H., Yarnitsky, D., ... Raja, S. N. (2017). Neuropathic pain. DOI: 10.1038/nrdp.2017.2

Neuropathic pain. / Colloca, Luana; Ludman, Taylor; Bouhassira, Didier; Baron, Ralf; Dickenson, Anthony H.; Yarnitsky, David; Freeman, Roy; Truini, Andrea; Attal, Nadine; Finnerup, Nanna B.; Eccleston, Christopher; Kalso, Eija; Bennett, David L.; Dworkin, Robert H.; Raja, Srinivasa N.

In: Nature Reviews Disease Primers, Vol. 3, 17002, 16.02.2017.

Research output: Contribution to journalArticle

Colloca, L, Ludman, T, Bouhassira, D, Baron, R, Dickenson, AH, Yarnitsky, D, Freeman, R, Truini, A, Attal, N, Finnerup, NB, Eccleston, C, Kalso, E, Bennett, DL, Dworkin, RH & Raja, SN 2017, 'Neuropathic pain' Nature Reviews Disease Primers, vol. 3, 17002. DOI: 10.1038/nrdp.2017.2
Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D et al. Neuropathic pain. Nature Reviews Disease Primers. 2017 Feb 16;3. 17002. Available from, DOI: 10.1038/nrdp.2017.2
Colloca, Luana ; Ludman, Taylor ; Bouhassira, Didier ; Baron, Ralf ; Dickenson, Anthony H. ; Yarnitsky, David ; Freeman, Roy ; Truini, Andrea ; Attal, Nadine ; Finnerup, Nanna B. ; Eccleston, Christopher ; Kalso, Eija ; Bennett, David L. ; Dworkin, Robert H. ; Raja, Srinivasa N./ Neuropathic pain. In: Nature Reviews Disease Primers. 2017 ; Vol. 3.
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