Neuro-cognitive performance in children with type 1 diabetes - A meta-analysis

Justine M Naguib, Elena Kulinskaya, Claire L Lomax, M Garralda

Research output: Contribution to journalArticle

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Abstract

Objective: To conduct meta-analyses of neuropsychological performance in young people with type 1 diabetes. Methods: Meta-analysis of 24 studies. Studies published between 1980 and 2005 were identified. The inclusion criteria were: young people who were less than =19 years of age with type 1 diabetes, a case-control design and standardized neuropsychological tests of seven cognitive domains.
Results: Diabetes was statistically associated with poorer performance on visuospatial ability (d = -0.29), motor speed (d = -0.26) and writing (d = -0.28), on sustained attention (d = -0.21) and reading (d = -0.23). Smaller effects were identified on full IQ (d = -0.14), on performance (d = -0.18) and verbal IQ (d = -0.15). Severe hypoglycemia was linked to deficits in short-term verbal memory (d = -0.14; Confidence Interval: -0.318, 0.024; p = .04).
Conclusions: This meta-analysis indicates that children with type 1 diabetes have mild cognitive impairments and subtly reduced overall intellectual functioning.
LanguageEnglish
Pages271-282
Number of pages12
JournalJournal of Pediatric Psychology
Volume34
Issue number3
DOIs
StatusPublished - 2009

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Type 1 Diabetes Mellitus
Meta-Analysis
Aptitude
Neuropsychological Tests
Short-Term Memory
Hypoglycemia
Reading
Confidence Intervals

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Naguib, J. M., Kulinskaya, E., Lomax, C. L., & Garralda, M. (2009). Neuro-cognitive performance in children with type 1 diabetes - A meta-analysis. Journal of Pediatric Psychology, 34(3), 271-282. DOI: 10.1093/jpepsy/jsn074

Neuro-cognitive performance in children with type 1 diabetes - A meta-analysis. / Naguib, Justine M; Kulinskaya, Elena; Lomax, Claire L; Garralda, M.

In: Journal of Pediatric Psychology, Vol. 34, No. 3, 2009, p. 271-282.

Research output: Contribution to journalArticle

Naguib, JM, Kulinskaya, E, Lomax, CL & Garralda, M 2009, 'Neuro-cognitive performance in children with type 1 diabetes - A meta-analysis' Journal of Pediatric Psychology, vol 34, no. 3, pp. 271-282. DOI: 10.1093/jpepsy/jsn074
Naguib JM, Kulinskaya E, Lomax CL, Garralda M. Neuro-cognitive performance in children with type 1 diabetes - A meta-analysis. Journal of Pediatric Psychology. 2009;34(3):271-282. Available from, DOI: 10.1093/jpepsy/jsn074
Naguib, Justine M ; Kulinskaya, Elena ; Lomax, Claire L ; Garralda, M. / Neuro-cognitive performance in children with type 1 diabetes - A meta-analysis. In: Journal of Pediatric Psychology. 2009 ; Vol. 34, No. 3. pp. 271-282
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