TY - JOUR
T1 - Neo¬clerodane diterpenoids from Reehal Fatima, Teucrium yemense
AU - Nur-e-Alam, Mohammad
AU - Yousaf, Muhammad
AU - Ahmed, Sarfaraz
AU - Al-Sheddi, Ebtesam S.
AU - Parveen, Ifat
AU - Fazakerley, David M.
AU - Bari, Ahmed
AU - Ghabbour, Hazem A.
AU - Threadgill, Michael
AU - Whatley, Kezia C. L.
AU - Hoffmann, Karl F.
AU - Al-Rehaily, Adnan N.
PY - 2017/6/23
Y1 - 2017/6/23
N2 - Teucrium yemense (Defl) (T. yemense), locally known as Reehal Fatima, is a medicinal plant commonly grown in Saudi Arabia and Yemen. Phytochemical investigation of the aerial parts of T. yemense yielded six new neoclerodane diterpenoids, namely fatimanol A-E (1, 2, 3, 5, 6) and fatimanone (4), and the known teulepicephin (7). As both the Teucrium genus and the related Lamiaceae family have previously been widely reported to possess anthelmintic and antimicrobial activities, the structural and biological characterisation of the seven diterpenoids was pursued. The structures of the new compounds were elucidated from their 2D NMR and MS profiles, and by comparison to related compounds. The structure of fatimanol D (5) was confirmed by X-ray crystallographic analysis. The new structures contribute to the breadth of knowledge of secondary metabolites in this genus.
AB - Teucrium yemense (Defl) (T. yemense), locally known as Reehal Fatima, is a medicinal plant commonly grown in Saudi Arabia and Yemen. Phytochemical investigation of the aerial parts of T. yemense yielded six new neoclerodane diterpenoids, namely fatimanol A-E (1, 2, 3, 5, 6) and fatimanone (4), and the known teulepicephin (7). As both the Teucrium genus and the related Lamiaceae family have previously been widely reported to possess anthelmintic and antimicrobial activities, the structural and biological characterisation of the seven diterpenoids was pursued. The structures of the new compounds were elucidated from their 2D NMR and MS profiles, and by comparison to related compounds. The structure of fatimanol D (5) was confirmed by X-ray crystallographic analysis. The new structures contribute to the breadth of knowledge of secondary metabolites in this genus.
UR - http://dx.doi.org/10.1021/acs.jnatprod.7b00188
U2 - 10.1021/acs.jnatprod.7b00188
DO - 10.1021/acs.jnatprod.7b00188
M3 - Article
SN - 0163-3864
VL - 80
SP - 1900
EP - 1908
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 6
ER -