Neo¬clerodane diterpenoids from Reehal Fatima, Teucrium yemense

Mohammad Nur-e-Alam, Muhammad Yousaf, Sarfaraz Ahmed, Ebtesam S. Al-Sheddi, Ifat Parveen, David M. Fazakerley, Ahmed Bari, Hazem A. Ghabbour, Michael Threadgill, Kezia C. L. Whatley, Karl F. Hoffmann, Adnan N. Al-Rehaily

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Abstract

Teucrium yemense (Defl) (T. yemense), locally known as Reehal Fatima, is a medicinal plant commonly grown in Saudi Arabia and Yemen. Phytochemical investigation of the aerial parts of T. yemense yielded six new neoclerodane diterpenoids, namely fatimanol A-E (1, 2, 3, 5, 6) and fatimanone (4), and the known teulepicephin (7). As both the Teucrium genus and the related Lamiaceae family have previously been widely reported to possess anthelmintic and antimicrobial activities, the structural and biological characterisation of the seven diterpenoids was pursued. The structures of the new compounds were elucidated from their 2D NMR and MS profiles, and by comparison to related compounds. The structure of fatimanol D (5) was confirmed by X-ray crystallographic analysis. The new structures contribute to the breadth of knowledge of secondary metabolites in this genus.
Original languageEnglish
Pages (from-to)1900-1908
JournalJournal of Natural Products
Volume80
Issue number6
DOIs
Publication statusPublished - 23 Jun 2017

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    Nur-e-Alam, M., Yousaf, M., Ahmed, S., Al-Sheddi, E. S., Parveen, I., Fazakerley, D. M., Bari, A., Ghabbour, H. A., Threadgill, M., Whatley, K. C. L., Hoffmann, K. F., & Al-Rehaily, A. N. (2017). Neo¬clerodane diterpenoids from Reehal Fatima, Teucrium yemense. Journal of Natural Products, 80(6), 1900-1908. https://doi.org/10.1021/acs.jnatprod.7b00188