Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

Ming Zhou; Hui Qi Gan; Guo Rong Chen; Tony D. James; Bin Zhang; Qiang Hu; Fugui Xu; Xi Le Hu; Xiao Peng He; Yiyong Mai

doi:10.3389/fchem.2021.767847

Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

Ming Zhou
, Hui Qi Gan
, Guo Rong Chen
, Tony D. James
, Bin Zhang
, Qiang Hu
, Fugui Xu
, Xi Le Hu
, Xiao Peng He
, Yiyong Mai

Shanghai Xuhui District Dahua Hospital
East China University of Science and Technology
Henan Normal University
Shanghai Jiao Tong University

Research output: Contribution to journal › Article › peer-review

5 Citations (SciVal)

Abstract

Bacterial infection is a major threat to human health. However, many antibacterial agents currently used are severely limited due to drug-resistance, and the development of side effects. Herein, we have developed a non-antibiotic nanocomposite consisting of chitosan (ChS) coated silver nanoparticles (AgNPs) and graphene nanoribbon (GNR)-based nanowires for light-triggered eradication of bacteria. The presence of AgNP/ChS significantly enhanced the interactions of the GNR nanowires with Pseudomonas aeruginosa, a clinically common Gram-negative bacterium. Which enables the highly effective photothermal eradication of bacteria by GNR upon near-infrared light irradiation. The nanocomposite was shown to be applicable for the light-triggered eradication of bacterial biofilms and the inhibition of bacterial growth on medical patches used for abdominal-wall hernia surgery.

Original language	English
Article number	767847
Journal	Frontiers in Chemistry
Volume	9
DOIs	https://doi.org/10.3389/fchem.2021.767847
Publication status	Published - 27 Oct 2021

Bibliographical note

Funding Information:
The authors thank the Natural National Science Foundation of China (NSFC) (Nos. 21907030 and 21774076), the Program of Shanghai Academic Research Leader (19XD1421700), the Shanghai Eastern Scholar Program, the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the international cooperation program of Shanghai Science and Technology Committee (17520750100) and the China Postdoctoral Science Foundation (2020TQ0188). TJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

Funding

The authors thank the Natural National Science Foundation of China (NSFC) (Nos. 21907030 and 21774076), the Program of Shanghai Academic Research Leader (19XD1421700), the Shanghai Eastern Scholar Program, the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the international cooperation program of Shanghai Science and Technology Committee (17520750100) and the China Postdoctoral Science Foundation (2020TQ0188). TJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

antibiotic
chitosan
graphene nanoribbons
nanocomposite
silver nanoparticles

ASJC Scopus subject areas

General Chemistry

Access to Document

10.3389/fchem.2021.767847Licence: CC BY

Cite this

@article{ceda933e705e4555b012d87e79dcfad1,

title = "Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles",

abstract = "Bacterial infection is a major threat to human health. However, many antibacterial agents currently used are severely limited due to drug-resistance, and the development of side effects. Herein, we have developed a non-antibiotic nanocomposite consisting of chitosan (ChS) coated silver nanoparticles (AgNPs) and graphene nanoribbon (GNR)-based nanowires for light-triggered eradication of bacteria. The presence of AgNP/ChS significantly enhanced the interactions of the GNR nanowires with Pseudomonas aeruginosa, a clinically common Gram-negative bacterium. Which enables the highly effective photothermal eradication of bacteria by GNR upon near-infrared light irradiation. The nanocomposite was shown to be applicable for the light-triggered eradication of bacterial biofilms and the inhibition of bacterial growth on medical patches used for abdominal-wall hernia surgery.",

keywords = "antibiotic, chitosan, graphene nanoribbons, nanocomposite, silver nanoparticles",

author = "Ming Zhou and Gan, \{Hui Qi\} and Chen, \{Guo Rong\} and James, \{Tony D.\} and Bin Zhang and Qiang Hu and Fugui Xu and Hu, \{Xi Le\} and He, \{Xiao Peng\} and Yiyong Mai",

note = "Funding Information: The authors thank the Natural National Science Foundation of China (NSFC) (Nos. 21907030 and 21774076), the Program of Shanghai Academic Research Leader (19XD1421700), the Shanghai Eastern Scholar Program, the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the international cooperation program of Shanghai Science and Technology Committee (17520750100) and the China Postdoctoral Science Foundation (2020TQ0188). TJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). ",

year = "2021",

month = oct,

day = "27",

doi = "10.3389/fchem.2021.767847",

language = "English",

volume = "9",

journal = "Frontiers in Chemistry",

issn = "2296-2646",

publisher = "Frontiers Media SA",

}

TY - JOUR

T1 - Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

AU - Zhou, Ming

AU - Gan, Hui Qi

AU - Chen, Guo Rong

AU - James, Tony D.

AU - Zhang, Bin

AU - Hu, Qiang

AU - Xu, Fugui

AU - Hu, Xi Le

AU - He, Xiao Peng

AU - Mai, Yiyong

N1 - Funding Information: The authors thank the Natural National Science Foundation of China (NSFC) (Nos. 21907030 and 21774076), the Program of Shanghai Academic Research Leader (19XD1421700), the Shanghai Eastern Scholar Program, the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the international cooperation program of Shanghai Science and Technology Committee (17520750100) and the China Postdoctoral Science Foundation (2020TQ0188). TJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

PY - 2021/10/27

Y1 - 2021/10/27

N2 - Bacterial infection is a major threat to human health. However, many antibacterial agents currently used are severely limited due to drug-resistance, and the development of side effects. Herein, we have developed a non-antibiotic nanocomposite consisting of chitosan (ChS) coated silver nanoparticles (AgNPs) and graphene nanoribbon (GNR)-based nanowires for light-triggered eradication of bacteria. The presence of AgNP/ChS significantly enhanced the interactions of the GNR nanowires with Pseudomonas aeruginosa, a clinically common Gram-negative bacterium. Which enables the highly effective photothermal eradication of bacteria by GNR upon near-infrared light irradiation. The nanocomposite was shown to be applicable for the light-triggered eradication of bacterial biofilms and the inhibition of bacterial growth on medical patches used for abdominal-wall hernia surgery.

AB - Bacterial infection is a major threat to human health. However, many antibacterial agents currently used are severely limited due to drug-resistance, and the development of side effects. Herein, we have developed a non-antibiotic nanocomposite consisting of chitosan (ChS) coated silver nanoparticles (AgNPs) and graphene nanoribbon (GNR)-based nanowires for light-triggered eradication of bacteria. The presence of AgNP/ChS significantly enhanced the interactions of the GNR nanowires with Pseudomonas aeruginosa, a clinically common Gram-negative bacterium. Which enables the highly effective photothermal eradication of bacteria by GNR upon near-infrared light irradiation. The nanocomposite was shown to be applicable for the light-triggered eradication of bacterial biofilms and the inhibition of bacterial growth on medical patches used for abdominal-wall hernia surgery.

KW - antibiotic

KW - chitosan

KW - graphene nanoribbons

KW - nanocomposite

KW - silver nanoparticles

UR - https://www.scopus.com/pages/publications/85118804263

U2 - 10.3389/fchem.2021.767847

DO - 10.3389/fchem.2021.767847

M3 - Article

AN - SCOPUS:85118804263

SN - 2296-2646

VL - 9

JO - Frontiers in Chemistry

JF - Frontiers in Chemistry

M1 - 767847

ER -

Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this