Near-Infrared Light-Triggered Bacterial Eradication Using a Nanowire Nanocomposite of Graphene Nanoribbons and Chitosan-Coated Silver Nanoparticles

Ming Zhou, Hui Qi Gan, Guo Rong Chen, Tony D. James, Bin Zhang, Qiang Hu, Fugui Xu, Xi Le Hu, Xiao Peng He, Yiyong Mai

Research output: Contribution to journalArticlepeer-review

4 Citations (SciVal)

Abstract

Bacterial infection is a major threat to human health. However, many antibacterial agents currently used are severely limited due to drug-resistance, and the development of side effects. Herein, we have developed a non-antibiotic nanocomposite consisting of chitosan (ChS) coated silver nanoparticles (AgNPs) and graphene nanoribbon (GNR)-based nanowires for light-triggered eradication of bacteria. The presence of AgNP/ChS significantly enhanced the interactions of the GNR nanowires with Pseudomonas aeruginosa, a clinically common Gram-negative bacterium. Which enables the highly effective photothermal eradication of bacteria by GNR upon near-infrared light irradiation. The nanocomposite was shown to be applicable for the light-triggered eradication of bacterial biofilms and the inhibition of bacterial growth on medical patches used for abdominal-wall hernia surgery.

Original languageEnglish
Article number767847
JournalFrontiers in Chemistry
Volume9
DOIs
Publication statusPublished - 27 Oct 2021

Bibliographical note

Funding Information:
The authors thank the Natural National Science Foundation of China (NSFC) (Nos. 21907030 and 21774076), the Program of Shanghai Academic Research Leader (19XD1421700), the Shanghai Eastern Scholar Program, the Shanghai Municipal Science and Technology Major Project (2018SHZDZX03), the National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the international cooperation program of Shanghai Science and Technology Committee (17520750100) and the China Postdoctoral Science Foundation (2020TQ0188). TJ wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01).

Keywords

  • antibiotic
  • chitosan
  • graphene nanoribbons
  • nanocomposite
  • silver nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)

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