Native RNA-Sequencing Throws its Hat into the Transcriptomics Ring

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De novo sequence-level surveys of transcriptomes have previously relied on sequencing via a DNA intermediate. While such methods can yield massive data sets, various problems mean that these do not always accurately reflect the true innate composition of transcriptomes. Enter Garalde et al., who present for the first time highly parallel native RNA-Sequencing (RNA-seq), with potentially disruptive future-implications for the transcriptomics field.
Original languageEnglish
Pages (from-to)225-227
Number of pages3
JournalTrends in Biochemical Sciences
Issue number4
Early online date1 Mar 2018
Publication statusPublished - 1 Apr 2018


  • MinION
  • ONT
  • Oxford Nanopore Technologies
  • RNA-Seq
  • alternative splicing
  • epitranscriptome
  • epitranscriptomics
  • nanopore sequencing

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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