Nanotechnology-based electrochemical biosensors for monitoring breast cancer biomarkers

Hassan Nasrollahpour, Balal Khalilzadeh, Mohammad Hasanzadeh, Reza Rahbarghazi, Pedro Estrela, Abdolhossein Naseri, Savas Tasoglu, Mika Sillanpää

Research output: Contribution to journalReview articlepeer-review

16 Citations (SciVal)
135 Downloads (Pure)


Breast cancer is categorized as the most widespread cancer type among women globally. On-time diagnosis can decrease the mortality rate by making the right decision in the therapy procedure. These features lead to a reduction in medication time and socio-economic burden. The current review article provides a comprehensive assessment for breast cancer diagnosis using nanomaterials and related technologies. Growing use of the nano/biotechnology domain in terms of electrochemical nanobiosensor designing was discussed in detail. In this regard, recent advances in nanomaterial applied for amplified biosensing methodologies were assessed for breast cancer diagnosis by focusing on the advantages and disadvantages of these approaches. We also monitored designing methods, advantages, and the necessity of suitable (nano) materials from a statistical standpoint. The main objective of this review is to classify the applicable biosensors based on breast cancer biomarkers. With numerous nano-sized platforms published for breast cancer diagnosis, this review tried to collect the most suitable methodologies for detecting biomarkers and certain breast cancer cell types.
Original languageEnglish
Pages (from-to)464-569
Number of pages106
JournalMedicinal Research Reviews
Issue number3
Early online date5 Dec 2022
Publication statusPublished - 1 May 2023

Bibliographical note

Funding Information:
The authors appreciate the support of this project by the Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. This project was financially supported by the Stem Cell Research Center, Tabriz University of Medical Sciences (Grant number: 67313). This project was approved by the regional ethics committee, IR.TBZMED.VCR.REC.1400.150.

Publisher Copyright:
© 2022 Wiley Periodicals LLC.


  • advanced nanomaterials
  • breast cancer
  • diagnosis
  • electrochemistry
  • nanotechnology

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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